Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control

Translation inhibition is a strategy for organisms to overcome various environmental stresses including viral infections. Here the authors show that a tRNA/rRNA-targeting RNase Schlafen13 inhibits protein synthesis by directly digesting cytoplasmic tRNA and rRNA with the ability to restrict viral pr...

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Autores principales:	Jin-Yu Yang, Xiang-Yu Deng, Yi-Sheng Li, Xian-Cai Ma, Jian-Xiong Feng, Bing Yu, Yang Chen, Yi-Ling Luo, Xi Wang, Mei-Ling Chen, Zhi-Xin Fang, Fu-Xiang Zheng, Yi-Ping Li, Qian Zhong, Tie-Bang Kang, Li-Bing Song, Rui-Hua Xu, Mu-Sheng Zeng, Wei Chen, Hui Zhang, Wei Xie, Song Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/19334f8a10ad4bdb82c317e1451abf22
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spelling	oai:doaj.org-article:19334f8a10ad4bdb82c317e1451abf222021-12-02T17:32:45ZStructure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control10.1038/s41467-018-03544-x2041-1723https://doaj.org/article/19334f8a10ad4bdb82c317e1451abf222018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03544-xhttps://doaj.org/toc/2041-1723Translation inhibition is a strategy for organisms to overcome various environmental stresses including viral infections. Here the authors show that a tRNA/rRNA-targeting RNase Schlafen13 inhibits protein synthesis by directly digesting cytoplasmic tRNA and rRNA with the ability to restrict viral propagation.Jin-Yu YangXiang-Yu DengYi-Sheng LiXian-Cai MaJian-Xiong FengBing YuYang ChenYi-Ling LuoXi WangMei-Ling ChenZhi-Xin FangFu-Xiang ZhengYi-Ping LiQian ZhongTie-Bang KangLi-Bing SongRui-Hua XuMu-Sheng ZengWei ChenHui ZhangWei XieSong GaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin-Yu Yang Xiang-Yu Deng Yi-Sheng Li Xian-Cai Ma Jian-Xiong Feng Bing Yu Yang Chen Yi-Ling Luo Xi Wang Mei-Ling Chen Zhi-Xin Fang Fu-Xiang Zheng Yi-Ping Li Qian Zhong Tie-Bang Kang Li-Bing Song Rui-Hua Xu Mu-Sheng Zeng Wei Chen Hui Zhang Wei Xie Song Gao Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control
description	Translation inhibition is a strategy for organisms to overcome various environmental stresses including viral infections. Here the authors show that a tRNA/rRNA-targeting RNase Schlafen13 inhibits protein synthesis by directly digesting cytoplasmic tRNA and rRNA with the ability to restrict viral propagation.
format	article
author	Jin-Yu Yang Xiang-Yu Deng Yi-Sheng Li Xian-Cai Ma Jian-Xiong Feng Bing Yu Yang Chen Yi-Ling Luo Xi Wang Mei-Ling Chen Zhi-Xin Fang Fu-Xiang Zheng Yi-Ping Li Qian Zhong Tie-Bang Kang Li-Bing Song Rui-Hua Xu Mu-Sheng Zeng Wei Chen Hui Zhang Wei Xie Song Gao
author_facet	Jin-Yu Yang Xiang-Yu Deng Yi-Sheng Li Xian-Cai Ma Jian-Xiong Feng Bing Yu Yang Chen Yi-Ling Luo Xi Wang Mei-Ling Chen Zhi-Xin Fang Fu-Xiang Zheng Yi-Ping Li Qian Zhong Tie-Bang Kang Li-Bing Song Rui-Hua Xu Mu-Sheng Zeng Wei Chen Hui Zhang Wei Xie Song Gao
author_sort	Jin-Yu Yang
title	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control
title_short	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control
title_full	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control
title_fullStr	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control
title_full_unstemmed	Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control
title_sort	structure of schlafen13 reveals a new class of trna/rrna- targeting rnase engaged in translational control
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/19334f8a10ad4bdb82c317e1451abf22
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Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control

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