Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory

The circular RNA named ciRS-7 is overexpressed in human cancers, however, its spatial cellular expression patterns have not been explored. Here, the authors show that ciRS-7 is not expressed in colon cancer cells, but abundant in stromal cells within tumours, and that cancer-to-stromal cell ratios c...

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Autores principales:	Lasse S. Kristensen, Karoline K. Ebbesen, Martin Sokol, Theresa Jakobsen, Ulrik Korsgaard, Ann C. Eriksen, Thomas B. Hansen, Jørgen Kjems, Henrik Hager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1936aeae5ae645e7b1b908e2113e8300
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id	oai:doaj.org-article:1936aeae5ae645e7b1b908e2113e8300
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spelling	oai:doaj.org-article:1936aeae5ae645e7b1b908e2113e83002021-12-02T19:13:48ZSpatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory10.1038/s41467-020-18355-22041-1723https://doaj.org/article/1936aeae5ae645e7b1b908e2113e83002020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18355-2https://doaj.org/toc/2041-1723The circular RNA named ciRS-7 is overexpressed in human cancers, however, its spatial cellular expression patterns have not been explored. Here, the authors show that ciRS-7 is not expressed in colon cancer cells, but abundant in stromal cells within tumours, and that cancer-to-stromal cell ratios contribute to correlations between ciRS-7 and miR-7 target genes.Lasse S. KristensenKaroline K. EbbesenMartin SokolTheresa JakobsenUlrik KorsgaardAnn C. EriksenThomas B. HansenJørgen KjemsHenrik HagerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lasse S. Kristensen Karoline K. Ebbesen Martin Sokol Theresa Jakobsen Ulrik Korsgaard Ann C. Eriksen Thomas B. Hansen Jørgen Kjems Henrik Hager Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory
description	The circular RNA named ciRS-7 is overexpressed in human cancers, however, its spatial cellular expression patterns have not been explored. Here, the authors show that ciRS-7 is not expressed in colon cancer cells, but abundant in stromal cells within tumours, and that cancer-to-stromal cell ratios contribute to correlations between ciRS-7 and miR-7 target genes.
format	article
author	Lasse S. Kristensen Karoline K. Ebbesen Martin Sokol Theresa Jakobsen Ulrik Korsgaard Ann C. Eriksen Thomas B. Hansen Jørgen Kjems Henrik Hager
author_facet	Lasse S. Kristensen Karoline K. Ebbesen Martin Sokol Theresa Jakobsen Ulrik Korsgaard Ann C. Eriksen Thomas B. Hansen Jørgen Kjems Henrik Hager
author_sort	Lasse S. Kristensen
title	Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory
title_short	Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory
title_full	Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory
title_fullStr	Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory
title_full_unstemmed	Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory
title_sort	spatial expression analyses of the putative oncogene cirs-7 in cancer reshape the microrna sponge theory
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1936aeae5ae645e7b1b908e2113e8300
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Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory

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