Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands

The D2 dopamine receptor (DRD2) is one of the most well-established therapeutic targets for neuropsychiatric and endocrine disorders. Here, the authors report the crystal structure of the antipsychotic drug haloperidol bound to DRD2 via an extended binding pocket that distinguishes it from other D2-...

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Autores principales:	Luyu Fan, Liang Tan, Zhangcheng Chen, Jianzhong Qi, Fen Nie, Zhipu Luo, Jianjun Cheng, Sheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1936baecc46a4ba180565c58eeea1187
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spelling	oai:doaj.org-article:1936baecc46a4ba180565c58eeea11872021-12-02T14:41:03ZHaloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands10.1038/s41467-020-14884-y2041-1723https://doaj.org/article/1936baecc46a4ba180565c58eeea11872020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14884-yhttps://doaj.org/toc/2041-1723The D2 dopamine receptor (DRD2) is one of the most well-established therapeutic targets for neuropsychiatric and endocrine disorders. Here, the authors report the crystal structure of the antipsychotic drug haloperidol bound to DRD2 via an extended binding pocket that distinguishes it from other D2-like subtypes.Luyu FanLiang TanZhangcheng ChenJianzhong QiFen NieZhipu LuoJianjun ChengSheng WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luyu Fan Liang Tan Zhangcheng Chen Jianzhong Qi Fen Nie Zhipu Luo Jianjun Cheng Sheng Wang Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
description	The D2 dopamine receptor (DRD2) is one of the most well-established therapeutic targets for neuropsychiatric and endocrine disorders. Here, the authors report the crystal structure of the antipsychotic drug haloperidol bound to DRD2 via an extended binding pocket that distinguishes it from other D2-like subtypes.
format	article
author	Luyu Fan Liang Tan Zhangcheng Chen Jianzhong Qi Fen Nie Zhipu Luo Jianjun Cheng Sheng Wang
author_facet	Luyu Fan Liang Tan Zhangcheng Chen Jianzhong Qi Fen Nie Zhipu Luo Jianjun Cheng Sheng Wang
author_sort	Luyu Fan
title	Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
title_short	Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
title_full	Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
title_fullStr	Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
title_full_unstemmed	Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands
title_sort	haloperidol bound d2 dopamine receptor structure inspired the discovery of subtype selective ligands
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1936baecc46a4ba180565c58eeea1187
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Haloperidol bound D2 dopamine receptor structure inspired the discovery of subtype selective ligands

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