Pre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention

Abstract The impact of pre-existing depression on mortality in individuals with established coronary artery disease (CAD) remains unclear. We evaluate the clinical implications of pre-existing depression in patients who underwent percutaneous coronary intervention (PCI). Based on National Health Ins...

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Autores principales:	Jangho Park, Sangwoo Park, Yong-Giun Kim, Soe Hee Ann, Hyun Woo Park, Jon Suh, Jae-Hyung Roh, Young-Rak Cho, Seungbong Han, Gyung-Min Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19373d06bde94ddeb77101a3819582e9
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spelling	oai:doaj.org-article:19373d06bde94ddeb77101a3819582e92021-12-02T18:27:48ZPre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention10.1038/s41598-021-87907-32045-2322https://doaj.org/article/19373d06bde94ddeb77101a3819582e92021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87907-3https://doaj.org/toc/2045-2322Abstract The impact of pre-existing depression on mortality in individuals with established coronary artery disease (CAD) remains unclear. We evaluate the clinical implications of pre-existing depression in patients who underwent percutaneous coronary intervention (PCI). Based on National Health Insurance claims data in Korea, patients without a known history of CAD who underwent PCI between 2013 and 2017 were enrolled. The study population was divided into patients with angina (n = 50,256) or acute myocardial infarction (AMI; n = 40,049). The primary endpoint, defined as all-cause death, was compared between the non-depression and depression groups using propensity score matching analysis. After propensity score matching, there were 4262 and 2346 matched pairs of patients with angina and AMI, respectively. During the follow-up period, there was no significant difference in the incidence of all-cause death in the angina (hazard ratio [HR] of depression, 1.013; 95% confidence interval [CI] 0.893–1.151) and AMI (HR, 0.991; 95% CI 0.865–1.136) groups. However, angina patients less than 65 years of age with depression had higher all-cause mortality (HR, 1.769; 95% CI 1.240–2.525). In Korean patients undergoing PCI, pre-existing depression is not associated with poorer clinical outcomes. However, in younger patients with angina, depression is associated with higher all-cause mortality.Jangho ParkSangwoo ParkYong-Giun KimSoe Hee AnnHyun Woo ParkJon SuhJae-Hyung RohYoung-Rak ChoSeungbong HanGyung-Min ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jangho Park Sangwoo Park Yong-Giun Kim Soe Hee Ann Hyun Woo Park Jon Suh Jae-Hyung Roh Young-Rak Cho Seungbong Han Gyung-Min Park Pre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention
description	Abstract The impact of pre-existing depression on mortality in individuals with established coronary artery disease (CAD) remains unclear. We evaluate the clinical implications of pre-existing depression in patients who underwent percutaneous coronary intervention (PCI). Based on National Health Insurance claims data in Korea, patients without a known history of CAD who underwent PCI between 2013 and 2017 were enrolled. The study population was divided into patients with angina (n = 50,256) or acute myocardial infarction (AMI; n = 40,049). The primary endpoint, defined as all-cause death, was compared between the non-depression and depression groups using propensity score matching analysis. After propensity score matching, there were 4262 and 2346 matched pairs of patients with angina and AMI, respectively. During the follow-up period, there was no significant difference in the incidence of all-cause death in the angina (hazard ratio [HR] of depression, 1.013; 95% confidence interval [CI] 0.893–1.151) and AMI (HR, 0.991; 95% CI 0.865–1.136) groups. However, angina patients less than 65 years of age with depression had higher all-cause mortality (HR, 1.769; 95% CI 1.240–2.525). In Korean patients undergoing PCI, pre-existing depression is not associated with poorer clinical outcomes. However, in younger patients with angina, depression is associated with higher all-cause mortality.
format	article
author	Jangho Park Sangwoo Park Yong-Giun Kim Soe Hee Ann Hyun Woo Park Jon Suh Jae-Hyung Roh Young-Rak Cho Seungbong Han Gyung-Min Park
author_facet	Jangho Park Sangwoo Park Yong-Giun Kim Soe Hee Ann Hyun Woo Park Jon Suh Jae-Hyung Roh Young-Rak Cho Seungbong Han Gyung-Min Park
author_sort	Jangho Park
title	Pre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention
title_short	Pre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention
title_full	Pre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention
title_fullStr	Pre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention
title_full_unstemmed	Pre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention
title_sort	pre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/19373d06bde94ddeb77101a3819582e9
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Pre-existing depression in patients with coronary artery disease undergoing percutaneous coronary intervention

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