Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates

Antibody-drug conjugates targeting high expression receptors can suffer from poor tumour penetration. Here, the authors use unconjugated antibody to improve the penetration of an antibody-dye conjugate in a clinical study, supporting further clinical investigation of the co-administration strategy.

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Autores principales:	Guolan Lu, Naoki Nishio, Nynke S. van den Berg, Brock A. Martin, Shayan Fakurnejad, Stan van Keulen, Alexander D. Colevas, Greg M. Thurber, Eben L. Rosenthal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1938690d6e61435ab3bfc4f49f1afa68
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spelling	oai:doaj.org-article:1938690d6e61435ab3bfc4f49f1afa682021-12-02T16:56:32ZCo-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates10.1038/s41467-020-19498-y2041-1723https://doaj.org/article/1938690d6e61435ab3bfc4f49f1afa682020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19498-yhttps://doaj.org/toc/2041-1723Antibody-drug conjugates targeting high expression receptors can suffer from poor tumour penetration. Here, the authors use unconjugated antibody to improve the penetration of an antibody-dye conjugate in a clinical study, supporting further clinical investigation of the co-administration strategy.Guolan LuNaoki NishioNynke S. van den BergBrock A. MartinShayan FakurnejadStan van KeulenAlexander D. ColevasGreg M. ThurberEben L. RosenthalNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guolan Lu Naoki Nishio Nynke S. van den Berg Brock A. Martin Shayan Fakurnejad Stan van Keulen Alexander D. Colevas Greg M. Thurber Eben L. Rosenthal Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates
description	Antibody-drug conjugates targeting high expression receptors can suffer from poor tumour penetration. Here, the authors use unconjugated antibody to improve the penetration of an antibody-dye conjugate in a clinical study, supporting further clinical investigation of the co-administration strategy.
format	article
author	Guolan Lu Naoki Nishio Nynke S. van den Berg Brock A. Martin Shayan Fakurnejad Stan van Keulen Alexander D. Colevas Greg M. Thurber Eben L. Rosenthal
author_facet	Guolan Lu Naoki Nishio Nynke S. van den Berg Brock A. Martin Shayan Fakurnejad Stan van Keulen Alexander D. Colevas Greg M. Thurber Eben L. Rosenthal
author_sort	Guolan Lu
title	Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates
title_short	Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates
title_full	Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates
title_fullStr	Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates
title_full_unstemmed	Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates
title_sort	co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1938690d6e61435ab3bfc4f49f1afa68
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Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates

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