Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

The glycolytic enzyme pyruvate kinase M2 (PKM2) is required for nucleotide synthesis and cell proliferation. Using gene expression and metabolomics analyses, the authors here show that PKM2 regulates methionine metabolism and DNA methylation in endothelial cells.

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Autores principales:	Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/193983107e6a406b9727e989c6776bf0
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spelling	oai:doaj.org-article:193983107e6a406b9727e989c6776bf02021-12-02T15:34:39ZLoss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells10.1038/s41467-018-06406-82041-1723https://doaj.org/article/193983107e6a406b9727e989c6776bf02018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06406-8https://doaj.org/toc/2041-1723The glycolytic enzyme pyruvate kinase M2 (PKM2) is required for nucleotide synthesis and cell proliferation. Using gene expression and metabolomics analyses, the authors here show that PKM2 regulates methionine metabolism and DNA methylation in endothelial cells.Oliver A. StoneMohamed El-BrolosyKerstin WilhelmXiaojing LiuAna M. RomãoElisabetta GrilloJason K. H. LaiStefan GüntherSylvia JeratschCarsten KuenneI-Ching LeeThomas BraunMassimo M. SantoroJason W. LocasaleMichael PotenteDidier Y. R. StainierNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oliver A. Stone Mohamed El-Brolosy Kerstin Wilhelm Xiaojing Liu Ana M. Romão Elisabetta Grillo Jason K. H. Lai Stefan Günther Sylvia Jeratsch Carsten Kuenne I-Ching Lee Thomas Braun Massimo M. Santoro Jason W. Locasale Michael Potente Didier Y. R. Stainier Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
description	The glycolytic enzyme pyruvate kinase M2 (PKM2) is required for nucleotide synthesis and cell proliferation. Using gene expression and metabolomics analyses, the authors here show that PKM2 regulates methionine metabolism and DNA methylation in endothelial cells.
format	article
author	Oliver A. Stone Mohamed El-Brolosy Kerstin Wilhelm Xiaojing Liu Ana M. Romão Elisabetta Grillo Jason K. H. Lai Stefan Günther Sylvia Jeratsch Carsten Kuenne I-Ching Lee Thomas Braun Massimo M. Santoro Jason W. Locasale Michael Potente Didier Y. R. Stainier
author_facet	Oliver A. Stone Mohamed El-Brolosy Kerstin Wilhelm Xiaojing Liu Ana M. Romão Elisabetta Grillo Jason K. H. Lai Stefan Günther Sylvia Jeratsch Carsten Kuenne I-Ching Lee Thomas Braun Massimo M. Santoro Jason W. Locasale Michael Potente Didier Y. R. Stainier
author_sort	Oliver A. Stone
title	Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
title_short	Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
title_full	Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
title_fullStr	Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
title_full_unstemmed	Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
title_sort	loss of pyruvate kinase m2 limits growth and triggers innate immune signaling in endothelial cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/193983107e6a406b9727e989c6776bf0
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Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

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