Vitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients

Introduction Ischaemic heart disease is the main cause of death in developed countries. There are many modifiable risk factors associated with coronary heart disease (CAD). A growing number of studies point to vitamin D deficiency as a risk factor for heart attacks and the conditions associated with...

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Autores principales:	Ewelina A. Dziedzic, Jakub S. Gąsior, Mariusz Pawłowski, Beata Wodejko-Kucharska, Tomasz Saniewski, Anna Marcisz, Marek J. Dąbrowski
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	vitamin d coronary atherosclerosis cardiometabolic risk factors Medicine R
Acceso en línea:	https://doaj.org/article/193a5b74d7334e348202e0eacd0ab375
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spelling	oai:doaj.org-article:193a5b74d7334e348202e0eacd0ab3752021-12-02T16:59:25ZVitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients1734-19221896-915110.5114/aoms.2019.83291https://doaj.org/article/193a5b74d7334e348202e0eacd0ab3752019-03-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Vitamin-D-level-is-associated-with-severity-of-coronary-artery-atherosclerosis-and,69661,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Ischaemic heart disease is the main cause of death in developed countries. There are many modifiable risk factors associated with coronary heart disease (CAD). A growing number of studies point to vitamin D deficiency as a risk factor for heart attacks and the conditions associated with cardiovascular disease. This study aimed to analyse the relationship between the level of 25-hydroxyvitamin D (25(OH)D) and the severity of coronary artery atherosclerosis and to study 25(OH)D levels in non-diabetic patients hospitalised due to acute coronary syndrome and those diagnosed with stable CAD. Material and methods Coronary angiography was performed prospectively in 410 successive cardiac patients. The severity of coronary artery atherosclerosis was assessed according to the Coronary Artery Surgery Study Score (CASSS). The plasma 25(OH)D level was assessed with the electrochemiluminescence method. Results The 25(OH)D level proved to be one of the significant determinants of the CASSS (p < 0.05). In subjects without significant lesions in the coronary arteries the 25(OH)D level was significantly higher compared to patients with one- to three-vessel coronary atherosclerosis (p < 0.05). A significantly higher 25(OH)D level was noted in patients diagnosed with stable CAD compared to patients hospitalised due to acute coronary syndrome (p < 0.01). Conclusions Patients with one- to three-vessel atherosclerosis have a significantly lower 25(OH)D level compared to patients without significant lesions in the coronary arteries. A lower 25(OH)D level was observed in patients hospitalised due to acute coronary syndrome compared to patients diagnosed with stable CAD.Ewelina A. DziedzicJakub S. GąsiorMariusz PawłowskiBeata Wodejko-KucharskaTomasz SaniewskiAnna MarciszMarek J. DąbrowskiTermedia Publishing Housearticlevitamin dcoronary atherosclerosiscardiometabolic risk factorsMedicineRENArchives of Medical Science, Vol 15, Iss 2, Pp 359-368 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin d coronary atherosclerosis cardiometabolic risk factors Medicine R
spellingShingle	vitamin d coronary atherosclerosis cardiometabolic risk factors Medicine R Ewelina A. Dziedzic Jakub S. Gąsior Mariusz Pawłowski Beata Wodejko-Kucharska Tomasz Saniewski Anna Marcisz Marek J. Dąbrowski Vitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients
description	Introduction Ischaemic heart disease is the main cause of death in developed countries. There are many modifiable risk factors associated with coronary heart disease (CAD). A growing number of studies point to vitamin D deficiency as a risk factor for heart attacks and the conditions associated with cardiovascular disease. This study aimed to analyse the relationship between the level of 25-hydroxyvitamin D (25(OH)D) and the severity of coronary artery atherosclerosis and to study 25(OH)D levels in non-diabetic patients hospitalised due to acute coronary syndrome and those diagnosed with stable CAD. Material and methods Coronary angiography was performed prospectively in 410 successive cardiac patients. The severity of coronary artery atherosclerosis was assessed according to the Coronary Artery Surgery Study Score (CASSS). The plasma 25(OH)D level was assessed with the electrochemiluminescence method. Results The 25(OH)D level proved to be one of the significant determinants of the CASSS (p < 0.05). In subjects without significant lesions in the coronary arteries the 25(OH)D level was significantly higher compared to patients with one- to three-vessel coronary atherosclerosis (p < 0.05). A significantly higher 25(OH)D level was noted in patients diagnosed with stable CAD compared to patients hospitalised due to acute coronary syndrome (p < 0.01). Conclusions Patients with one- to three-vessel atherosclerosis have a significantly lower 25(OH)D level compared to patients without significant lesions in the coronary arteries. A lower 25(OH)D level was observed in patients hospitalised due to acute coronary syndrome compared to patients diagnosed with stable CAD.
format	article
author	Ewelina A. Dziedzic Jakub S. Gąsior Mariusz Pawłowski Beata Wodejko-Kucharska Tomasz Saniewski Anna Marcisz Marek J. Dąbrowski
author_facet	Ewelina A. Dziedzic Jakub S. Gąsior Mariusz Pawłowski Beata Wodejko-Kucharska Tomasz Saniewski Anna Marcisz Marek J. Dąbrowski
author_sort	Ewelina A. Dziedzic
title	Vitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients
title_short	Vitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients
title_full	Vitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients
title_fullStr	Vitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients
title_full_unstemmed	Vitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients
title_sort	vitamin d level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/193a5b74d7334e348202e0eacd0ab375
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Vitamin D level is associated with severity of coronary artery atherosclerosis and incidence of acute coronary syndromes in non-diabetic cardiac patients

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