Augmentation of working memory training by transcranial direct current stimulation (tDCS)

Abstract Transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (dlPFC) can modulate working memory (WM) performance. However, evidence regarding the enhancement of WM training, its sustainability and transferability is ambiguous. Since WM functioning appears to be late...

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Autores principales:	Steffen Philipp Ruf, Andreas J. Fallgatter, Christian Plewnia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/193a70bb25174772a07a8005dceb5ea5
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spelling	oai:doaj.org-article:193a70bb25174772a07a8005dceb5ea52021-12-02T12:30:27ZAugmentation of working memory training by transcranial direct current stimulation (tDCS)10.1038/s41598-017-01055-12045-2322https://doaj.org/article/193a70bb25174772a07a8005dceb5ea52017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01055-1https://doaj.org/toc/2045-2322Abstract Transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (dlPFC) can modulate working memory (WM) performance. However, evidence regarding the enhancement of WM training, its sustainability and transferability is ambiguous. Since WM functioning appears to be lateralized in respect to stimulus characteristics, this study examined the difference between task-congruent (spatial-right, verbal-left), task-incongruent (spatial-left, verbal-right) and sham tDCS in regards to the efficacy of WM training. In a randomized, sham-controlled experiment, 71 healthy adults trained on a spatial or verbal adaptive n-back task. After a baseline session, anodal or sham tDCS (1 mA) to the right or left dlPFC was applied during the next three training sessions. Sustainability of training gains and near-transfer (verbal or spatial 3-back task) were tested in a fourth training and a follow-up session. Compared to sham stimulation, we found a steeper learning curve when WM training was combined with task-congruent tDCS. This advantage was also present compared to task-incongruent tDCS. Moreover, these effects lasted for up to nine months and transferred to the respective untrained task. These long-lasting, transferable, task-specific effects demonstrate a behaviorally relevant and sustainable facilitation of neuroplastic processes by tDCS that could be harnessed for the treatment of disorders associated with deficient WM.Steffen Philipp RufAndreas J. FallgatterChristian PlewniaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Steffen Philipp Ruf Andreas J. Fallgatter Christian Plewnia Augmentation of working memory training by transcranial direct current stimulation (tDCS)
description	Abstract Transcranial direct current stimulation (tDCS) to the dorsolateral prefrontal cortex (dlPFC) can modulate working memory (WM) performance. However, evidence regarding the enhancement of WM training, its sustainability and transferability is ambiguous. Since WM functioning appears to be lateralized in respect to stimulus characteristics, this study examined the difference between task-congruent (spatial-right, verbal-left), task-incongruent (spatial-left, verbal-right) and sham tDCS in regards to the efficacy of WM training. In a randomized, sham-controlled experiment, 71 healthy adults trained on a spatial or verbal adaptive n-back task. After a baseline session, anodal or sham tDCS (1 mA) to the right or left dlPFC was applied during the next three training sessions. Sustainability of training gains and near-transfer (verbal or spatial 3-back task) were tested in a fourth training and a follow-up session. Compared to sham stimulation, we found a steeper learning curve when WM training was combined with task-congruent tDCS. This advantage was also present compared to task-incongruent tDCS. Moreover, these effects lasted for up to nine months and transferred to the respective untrained task. These long-lasting, transferable, task-specific effects demonstrate a behaviorally relevant and sustainable facilitation of neuroplastic processes by tDCS that could be harnessed for the treatment of disorders associated with deficient WM.
format	article
author	Steffen Philipp Ruf Andreas J. Fallgatter Christian Plewnia
author_facet	Steffen Philipp Ruf Andreas J. Fallgatter Christian Plewnia
author_sort	Steffen Philipp Ruf
title	Augmentation of working memory training by transcranial direct current stimulation (tDCS)
title_short	Augmentation of working memory training by transcranial direct current stimulation (tDCS)
title_full	Augmentation of working memory training by transcranial direct current stimulation (tDCS)
title_fullStr	Augmentation of working memory training by transcranial direct current stimulation (tDCS)
title_full_unstemmed	Augmentation of working memory training by transcranial direct current stimulation (tDCS)
title_sort	augmentation of working memory training by transcranial direct current stimulation (tdcs)
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/193a70bb25174772a07a8005dceb5ea5
work_keys_str_mv	AT steffenphilippruf augmentationofworkingmemorytrainingbytranscranialdirectcurrentstimulationtdcs AT andreasjfallgatter augmentationofworkingmemorytrainingbytranscranialdirectcurrentstimulationtdcs AT christianplewnia augmentationofworkingmemorytrainingbytranscranialdirectcurrentstimulationtdcs
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Augmentation of working memory training by transcranial direct current stimulation (tDCS)

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