Gastric Organoids: Progress and Remaining ChallengesSummary

The stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high...

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Autores principales: Min-Jiao Pang, Joseph R. Burclaff, Ramon Jin, Mahliyah Adkins-Threats, Luciana H. Osaki, Yunan Han, Jason C. Mills, Zhi-Feng Miao, Zhen-Ning Wang
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Publicado: Elsevier 2022
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Acceso en línea:https://doaj.org/article/193fd9b1e74b4b4bbbc6e0d2e64456dc
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spelling oai:doaj.org-article:193fd9b1e74b4b4bbbc6e0d2e64456dc2021-11-12T04:39:49ZGastric Organoids: Progress and Remaining ChallengesSummary2352-345X10.1016/j.jcmgh.2021.09.005https://doaj.org/article/193fd9b1e74b4b4bbbc6e0d2e64456dc2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352345X21001934https://doaj.org/toc/2352-345XThe stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high mortality rate and limited treatment options. The heterogeneous nature of GC makes it poorly suited for current “one size fits all” standard treatments. In this review, we discuss the rapidly evolving field of gastric organoids, with a focus on studies expanding cultures from primary human tissues and describing the benefits of mouse organoid models. We introduce the differing methods for culturing healthy gastric tissue from adult tissues or pluripotent stem cells, discuss the promise these systems have for preclinical drug screens, and highlight applications of organoids for precision medicine. Finally, we discuss the limitations of these models and look to the future to present potential ways gastric organoids will advance treatment options for patients with GC.Min-Jiao PangJoseph R. BurclaffRamon JinMahliyah Adkins-ThreatsLuciana H. OsakiYunan HanJason C. MillsZhi-Feng MiaoZhen-Ning WangElsevierarticleStomachOrganoidsGastric CancerTumor MicroenvironmentPreclinical TrialDiseases of the digestive system. GastroenterologyRC799-869ENCellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 19-33 (2022)
institution DOAJ
collection DOAJ
language EN
topic Stomach
Organoids
Gastric Cancer
Tumor Microenvironment
Preclinical Trial
Diseases of the digestive system. Gastroenterology
RC799-869
spellingShingle Stomach
Organoids
Gastric Cancer
Tumor Microenvironment
Preclinical Trial
Diseases of the digestive system. Gastroenterology
RC799-869
Min-Jiao Pang
Joseph R. Burclaff
Ramon Jin
Mahliyah Adkins-Threats
Luciana H. Osaki
Yunan Han
Jason C. Mills
Zhi-Feng Miao
Zhen-Ning Wang
Gastric Organoids: Progress and Remaining ChallengesSummary
description The stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high mortality rate and limited treatment options. The heterogeneous nature of GC makes it poorly suited for current “one size fits all” standard treatments. In this review, we discuss the rapidly evolving field of gastric organoids, with a focus on studies expanding cultures from primary human tissues and describing the benefits of mouse organoid models. We introduce the differing methods for culturing healthy gastric tissue from adult tissues or pluripotent stem cells, discuss the promise these systems have for preclinical drug screens, and highlight applications of organoids for precision medicine. Finally, we discuss the limitations of these models and look to the future to present potential ways gastric organoids will advance treatment options for patients with GC.
format article
author Min-Jiao Pang
Joseph R. Burclaff
Ramon Jin
Mahliyah Adkins-Threats
Luciana H. Osaki
Yunan Han
Jason C. Mills
Zhi-Feng Miao
Zhen-Ning Wang
author_facet Min-Jiao Pang
Joseph R. Burclaff
Ramon Jin
Mahliyah Adkins-Threats
Luciana H. Osaki
Yunan Han
Jason C. Mills
Zhi-Feng Miao
Zhen-Ning Wang
author_sort Min-Jiao Pang
title Gastric Organoids: Progress and Remaining ChallengesSummary
title_short Gastric Organoids: Progress and Remaining ChallengesSummary
title_full Gastric Organoids: Progress and Remaining ChallengesSummary
title_fullStr Gastric Organoids: Progress and Remaining ChallengesSummary
title_full_unstemmed Gastric Organoids: Progress and Remaining ChallengesSummary
title_sort gastric organoids: progress and remaining challengessummary
publisher Elsevier
publishDate 2022
url https://doaj.org/article/193fd9b1e74b4b4bbbc6e0d2e64456dc
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AT lucianahosaki gastricorganoidsprogressandremainingchallengessummary
AT yunanhan gastricorganoidsprogressandremainingchallengessummary
AT jasoncmills gastricorganoidsprogressandremainingchallengessummary
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