Gastric Organoids: Progress and Remaining ChallengesSummary
The stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high...
Guardado en:
Autores principales: | , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Elsevier
2022
|
Materias: | |
Acceso en línea: | https://doaj.org/article/193fd9b1e74b4b4bbbc6e0d2e64456dc |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:193fd9b1e74b4b4bbbc6e0d2e64456dc |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:193fd9b1e74b4b4bbbc6e0d2e64456dc2021-11-12T04:39:49ZGastric Organoids: Progress and Remaining ChallengesSummary2352-345X10.1016/j.jcmgh.2021.09.005https://doaj.org/article/193fd9b1e74b4b4bbbc6e0d2e64456dc2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352345X21001934https://doaj.org/toc/2352-345XThe stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high mortality rate and limited treatment options. The heterogeneous nature of GC makes it poorly suited for current “one size fits all” standard treatments. In this review, we discuss the rapidly evolving field of gastric organoids, with a focus on studies expanding cultures from primary human tissues and describing the benefits of mouse organoid models. We introduce the differing methods for culturing healthy gastric tissue from adult tissues or pluripotent stem cells, discuss the promise these systems have for preclinical drug screens, and highlight applications of organoids for precision medicine. Finally, we discuss the limitations of these models and look to the future to present potential ways gastric organoids will advance treatment options for patients with GC.Min-Jiao PangJoseph R. BurclaffRamon JinMahliyah Adkins-ThreatsLuciana H. OsakiYunan HanJason C. MillsZhi-Feng MiaoZhen-Ning WangElsevierarticleStomachOrganoidsGastric CancerTumor MicroenvironmentPreclinical TrialDiseases of the digestive system. GastroenterologyRC799-869ENCellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 19-33 (2022) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Stomach Organoids Gastric Cancer Tumor Microenvironment Preclinical Trial Diseases of the digestive system. Gastroenterology RC799-869 |
spellingShingle |
Stomach Organoids Gastric Cancer Tumor Microenvironment Preclinical Trial Diseases of the digestive system. Gastroenterology RC799-869 Min-Jiao Pang Joseph R. Burclaff Ramon Jin Mahliyah Adkins-Threats Luciana H. Osaki Yunan Han Jason C. Mills Zhi-Feng Miao Zhen-Ning Wang Gastric Organoids: Progress and Remaining ChallengesSummary |
description |
The stomach is a complex and physiologically necessary organ, yet large differences in physiology between mouse and human stomachs have impeded translation of physiological discoveries and drug screens performed using murine gastric tissues. Gastric cancer (GC) is a global health threat, with a high mortality rate and limited treatment options. The heterogeneous nature of GC makes it poorly suited for current “one size fits all” standard treatments. In this review, we discuss the rapidly evolving field of gastric organoids, with a focus on studies expanding cultures from primary human tissues and describing the benefits of mouse organoid models. We introduce the differing methods for culturing healthy gastric tissue from adult tissues or pluripotent stem cells, discuss the promise these systems have for preclinical drug screens, and highlight applications of organoids for precision medicine. Finally, we discuss the limitations of these models and look to the future to present potential ways gastric organoids will advance treatment options for patients with GC. |
format |
article |
author |
Min-Jiao Pang Joseph R. Burclaff Ramon Jin Mahliyah Adkins-Threats Luciana H. Osaki Yunan Han Jason C. Mills Zhi-Feng Miao Zhen-Ning Wang |
author_facet |
Min-Jiao Pang Joseph R. Burclaff Ramon Jin Mahliyah Adkins-Threats Luciana H. Osaki Yunan Han Jason C. Mills Zhi-Feng Miao Zhen-Ning Wang |
author_sort |
Min-Jiao Pang |
title |
Gastric Organoids: Progress and Remaining ChallengesSummary |
title_short |
Gastric Organoids: Progress and Remaining ChallengesSummary |
title_full |
Gastric Organoids: Progress and Remaining ChallengesSummary |
title_fullStr |
Gastric Organoids: Progress and Remaining ChallengesSummary |
title_full_unstemmed |
Gastric Organoids: Progress and Remaining ChallengesSummary |
title_sort |
gastric organoids: progress and remaining challengessummary |
publisher |
Elsevier |
publishDate |
2022 |
url |
https://doaj.org/article/193fd9b1e74b4b4bbbc6e0d2e64456dc |
work_keys_str_mv |
AT minjiaopang gastricorganoidsprogressandremainingchallengessummary AT josephrburclaff gastricorganoidsprogressandremainingchallengessummary AT ramonjin gastricorganoidsprogressandremainingchallengessummary AT mahliyahadkinsthreats gastricorganoidsprogressandremainingchallengessummary AT lucianahosaki gastricorganoidsprogressandremainingchallengessummary AT yunanhan gastricorganoidsprogressandremainingchallengessummary AT jasoncmills gastricorganoidsprogressandremainingchallengessummary AT zhifengmiao gastricorganoidsprogressandremainingchallengessummary AT zhenningwang gastricorganoidsprogressandremainingchallengessummary |
_version_ |
1718431215450587136 |