Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.

<h4>Background</h4>Many susceptible loci for type 2 diabetes mellitus (T2DM) have recently been identified from Caucasians through genome wide association studies (GWAS). We aimed to determine the association of 11 known loci with T2DM and impaired glucose regulation (IGR), individually...

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Autores principales:	Min Xu, Yufang Bi, Yu Xu, Bing Yu, Yun Huang, Lina Gu, Yaohua Wu, Xiaolin Zhu, Mian Li, Tiange Wang, Aiyun Song, Jianing Hou, Xiaoying Li, Guang Ning
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1941f50ee2534622a08516e22a8de7d5
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spelling	oai:doaj.org-article:1941f50ee2534622a08516e22a8de7d52021-11-18T07:36:45ZCombined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.1932-620310.1371/journal.pone.0014022https://doaj.org/article/1941f50ee2534622a08516e22a8de7d52010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21103332/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Many susceptible loci for type 2 diabetes mellitus (T2DM) have recently been identified from Caucasians through genome wide association studies (GWAS). We aimed to determine the association of 11 known loci with T2DM and impaired glucose regulation (IGR), individually and in combination, in Chinese.<h4>Methods/principal findings</h4>Subjects were enrolled in: (1) a case-control study including 1825 subjects with T2DM, 1487 with IGR and 2200 with normal glucose regulation; and (2) a prospective cohort with 734 non-diabetic subjects at baseline. The latter was followed up for 3.5 years, in which 67 subjects developed T2DM. Nineteen single nucleotide polymorphisms (SNPs) were selected to replicate in both studies. We found that CDKAL1 (rs7756992), SLC30A8 (rs13266634, rs2466293), CDKN2A/2B (rs10811661) and KCNQ1 (rs2237892) were associated with T2DM with odds ratio from 1.21 to 1.35. In the prospective study, the fourth quartile of risk scores based on the combined effects of the risk alleles had 3.05 folds (95% CI, 1.31-7.12) higher risk for incident T2DM as compared with the first quartile, after adjustment for age, gender, body mass index and diabetes family history. This combined effect was confirmed in the case-control study after the same adjustments. The addition of the risk scores to the model of clinical risk factors modestly improved discrimination for T2DM by 1.6% in the case-control study and 2.9% in the prospective study.<h4>Conclusions/significance</h4>Our study provided further evidence for these GWAS derived SNPs as the genetic susceptible loci for T2DM in Chinese and extended this association to IGR.Min XuYufang BiYu XuBing YuYun HuangLina GuYaohua WuXiaolin ZhuMian LiTiange WangAiyun SongJianing HouXiaoying LiGuang NingPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e14022 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min Xu Yufang Bi Yu Xu Bing Yu Yun Huang Lina Gu Yaohua Wu Xiaolin Zhu Mian Li Tiange Wang Aiyun Song Jianing Hou Xiaoying Li Guang Ning Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.
description	<h4>Background</h4>Many susceptible loci for type 2 diabetes mellitus (T2DM) have recently been identified from Caucasians through genome wide association studies (GWAS). We aimed to determine the association of 11 known loci with T2DM and impaired glucose regulation (IGR), individually and in combination, in Chinese.<h4>Methods/principal findings</h4>Subjects were enrolled in: (1) a case-control study including 1825 subjects with T2DM, 1487 with IGR and 2200 with normal glucose regulation; and (2) a prospective cohort with 734 non-diabetic subjects at baseline. The latter was followed up for 3.5 years, in which 67 subjects developed T2DM. Nineteen single nucleotide polymorphisms (SNPs) were selected to replicate in both studies. We found that CDKAL1 (rs7756992), SLC30A8 (rs13266634, rs2466293), CDKN2A/2B (rs10811661) and KCNQ1 (rs2237892) were associated with T2DM with odds ratio from 1.21 to 1.35. In the prospective study, the fourth quartile of risk scores based on the combined effects of the risk alleles had 3.05 folds (95% CI, 1.31-7.12) higher risk for incident T2DM as compared with the first quartile, after adjustment for age, gender, body mass index and diabetes family history. This combined effect was confirmed in the case-control study after the same adjustments. The addition of the risk scores to the model of clinical risk factors modestly improved discrimination for T2DM by 1.6% in the case-control study and 2.9% in the prospective study.<h4>Conclusions/significance</h4>Our study provided further evidence for these GWAS derived SNPs as the genetic susceptible loci for T2DM in Chinese and extended this association to IGR.
format	article
author	Min Xu Yufang Bi Yu Xu Bing Yu Yun Huang Lina Gu Yaohua Wu Xiaolin Zhu Mian Li Tiange Wang Aiyun Song Jianing Hou Xiaoying Li Guang Ning
author_facet	Min Xu Yufang Bi Yu Xu Bing Yu Yun Huang Lina Gu Yaohua Wu Xiaolin Zhu Mian Li Tiange Wang Aiyun Song Jianing Hou Xiaoying Li Guang Ning
author_sort	Min Xu
title	Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.
title_short	Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.
title_full	Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.
title_fullStr	Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.
title_full_unstemmed	Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.
title_sort	combined effects of 19 common variations on type 2 diabetes in chinese: results from two community-based studies.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/1941f50ee2534622a08516e22a8de7d5
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Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies.

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