Simultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. Clinical options

Simultaneous pancreas-kidney transplantation (SPKT) is the most promising treatment option for patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease (ESRD) due to diabetic nephropathy (DN). Successful SPKT eliminates uremic intoxication and hyperglycemia – the leading t...

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Autores principales:	A. S. Severina, I. I. Larina, A. S Shutovа, M. S. Shamkhalova, I. V. Dmitriev, Aleksey V. Pinchuk, S. V. Arzumanov, M. V. Shestakova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2020
Materias:	simultaneous pancreas-kidney transplants diabetes mellitus type 1 graft euglycemia case report Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/1944fc1d8ac2480390311cf9bdd54029
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spelling	oai:doaj.org-article:1944fc1d8ac2480390311cf9bdd540292021-11-14T09:00:23ZSimultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. Clinical options2072-03512072-037810.14341/DM12509https://doaj.org/article/1944fc1d8ac2480390311cf9bdd540292020-08-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12509https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Simultaneous pancreas-kidney transplantation (SPKT) is the most promising treatment option for patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease (ESRD) due to diabetic nephropathy (DN). Successful SPKT eliminates uremic intoxication and hyperglycemia – the leading trigger of vascular diabetic complications. Therefore, euglycemia is an important metabolic change in patients after surgery and remains only one of the factors for the saved renal allograft functioning. In the case of resuming renal replacement therapy by dialysis after SPKT, the management and monitoring of the pancreatic graft remains open. Special attention to the pancreatic graft’s function is due to both the potential risk of surgical complications, and some probability of T1DM relapse with the need to resume insulin therapy. In patients with saved function of both transplants, the assessment of the dynamics of diabetic complications in general becomes more important. The results of few studies in this regard remain contradictory. Thus, clinical options can be unpredictably diverse and require not only search for the root cause, but also optimization of rehabilitation tactics, even if the expected results are achieved.A. S. SeverinaI. I. LarinaA. S ShutovаM. S. ShamkhalovaI. V. DmitrievAleksey V. PinchukS. V. ArzumanovM. V. ShestakovaEndocrinology Research Centrearticlesimultaneous pancreas-kidney transplantsdiabetes mellitus type 1grafteuglycemiacase reportNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 23, Iss 3, Pp 275-282 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	simultaneous pancreas-kidney transplants diabetes mellitus type 1 graft euglycemia case report Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	simultaneous pancreas-kidney transplants diabetes mellitus type 1 graft euglycemia case report Nutritional diseases. Deficiency diseases RC620-627 A. S. Severina I. I. Larina A. S Shutovа M. S. Shamkhalova I. V. Dmitriev Aleksey V. Pinchuk S. V. Arzumanov M. V. Shestakova Simultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. Clinical options
description	Simultaneous pancreas-kidney transplantation (SPKT) is the most promising treatment option for patients with type 1 diabetes mellitus (T1DM) and end-stage renal disease (ESRD) due to diabetic nephropathy (DN). Successful SPKT eliminates uremic intoxication and hyperglycemia – the leading trigger of vascular diabetic complications. Therefore, euglycemia is an important metabolic change in patients after surgery and remains only one of the factors for the saved renal allograft functioning. In the case of resuming renal replacement therapy by dialysis after SPKT, the management and monitoring of the pancreatic graft remains open. Special attention to the pancreatic graft’s function is due to both the potential risk of surgical complications, and some probability of T1DM relapse with the need to resume insulin therapy. In patients with saved function of both transplants, the assessment of the dynamics of diabetic complications in general becomes more important. The results of few studies in this regard remain contradictory. Thus, clinical options can be unpredictably diverse and require not only search for the root cause, but also optimization of rehabilitation tactics, even if the expected results are achieved.
format	article
author	A. S. Severina I. I. Larina A. S Shutovа M. S. Shamkhalova I. V. Dmitriev Aleksey V. Pinchuk S. V. Arzumanov M. V. Shestakova
author_facet	A. S. Severina I. I. Larina A. S Shutovа M. S. Shamkhalova I. V. Dmitriev Aleksey V. Pinchuk S. V. Arzumanov M. V. Shestakova
author_sort	A. S. Severina
title	Simultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. Clinical options
title_short	Simultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. Clinical options
title_full	Simultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. Clinical options
title_fullStr	Simultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. Clinical options
title_full_unstemmed	Simultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. Clinical options
title_sort	simultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. clinical options
publisher	Endocrinology Research Centre
publishDate	2020
url	https://doaj.org/article/1944fc1d8ac2480390311cf9bdd54029
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Simultaneous pancreas‐kidney transplantation in type 1 diabetes mellitus. Clinical options

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