Breakthroughs in medicine and bioimaging with up-conversion nanoparticles

Iman Rostami,1,2 Hamideh Rezvani Alanagh,2 Zhiyuan Hu,2,3 Sarah H Shahmoradian1 1Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, Villigen, PSI 5232, Switzerland; 2CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Labo...

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Autores principales:	Rostami I, Rezvani Alanagh H, Hu Z, Shahmoradian SH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	up-conversion nanoparticles bioimaging theranostics therapy. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/19452981c33644e3a2b1b95962cf45a9
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spelling	oai:doaj.org-article:19452981c33644e3a2b1b95962cf45a92021-12-02T04:09:54ZBreakthroughs in medicine and bioimaging with up-conversion nanoparticles1178-2013https://doaj.org/article/19452981c33644e3a2b1b95962cf45a92019-09-01T00:00:00Zhttps://www.dovepress.com/breakthroughs-in-medicine-and-bioimaging-with-up-conversion-nanopartic-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Iman Rostami,1,2 Hamideh Rezvani Alanagh,2 Zhiyuan Hu,2,3 Sarah H Shahmoradian1 1Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, Villigen, PSI 5232, Switzerland; 2CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, People’s Republic of China; 3Center for Neuroscience Research, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province 350108, People’s Republic of ChinaCorrespondence: Iman RostamiPaul Scherrer Institute, OFLC/110, Forschungsstrasse 111, Villigen, PSI 5232, SwitzerlandTel +41 56 310 3309Email iman.rostami@psi.chAbstract: Nanomedicine is a medical application of biochemistry incorporated with materials chemistry at the scale of nanometer for the purpose of diagnosis, prevention, and treatment. New models and approaches are typically associated with nanomedicine for precise multifunctional diagnostic systems at molecular level. Hence, employing nanoparticles (NPs) has unveiled new opportunities for efficient therapies and remedy of difficult-to-cure diseases. Among all types of inorganic NPs, lanthanide-doped up-conversion nanoparticles (UCNPs) have shown excellent potential for biomedical applications, especially for multimodal bioimaging including fluorescence and electron microscopy. Association of these visualization techniques plus the capability for transporting biomaterials and drugs make them superior agents in the field of nanomedicine. Accordingly, in this review, we firstly presented a fundamental understanding of physical and optical properties of UCNPs and secondly, we illustrated some of the prominent associations with bioimaging, theranostics, cancer therapy, and optogenetics.Keywords: up-conversion nanoparticles, bioimaging, theranostics, therapyRostami IRezvani Alanagh HHu ZShahmoradian SHDove Medical Pressarticleup-conversion nanoparticlesbioimagingtheranosticstherapy.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 7759-7780 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	up-conversion nanoparticles bioimaging theranostics therapy. Medicine (General) R5-920
spellingShingle	up-conversion nanoparticles bioimaging theranostics therapy. Medicine (General) R5-920 Rostami I Rezvani Alanagh H Hu Z Shahmoradian SH Breakthroughs in medicine and bioimaging with up-conversion nanoparticles
description	Iman Rostami,1,2 Hamideh Rezvani Alanagh,2 Zhiyuan Hu,2,3 Sarah H Shahmoradian1 1Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, Villigen, PSI 5232, Switzerland; 2CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, People’s Republic of China; 3Center for Neuroscience Research, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province 350108, People’s Republic of ChinaCorrespondence: Iman RostamiPaul Scherrer Institute, OFLC/110, Forschungsstrasse 111, Villigen, PSI 5232, SwitzerlandTel +41 56 310 3309Email iman.rostami@psi.chAbstract: Nanomedicine is a medical application of biochemistry incorporated with materials chemistry at the scale of nanometer for the purpose of diagnosis, prevention, and treatment. New models and approaches are typically associated with nanomedicine for precise multifunctional diagnostic systems at molecular level. Hence, employing nanoparticles (NPs) has unveiled new opportunities for efficient therapies and remedy of difficult-to-cure diseases. Among all types of inorganic NPs, lanthanide-doped up-conversion nanoparticles (UCNPs) have shown excellent potential for biomedical applications, especially for multimodal bioimaging including fluorescence and electron microscopy. Association of these visualization techniques plus the capability for transporting biomaterials and drugs make them superior agents in the field of nanomedicine. Accordingly, in this review, we firstly presented a fundamental understanding of physical and optical properties of UCNPs and secondly, we illustrated some of the prominent associations with bioimaging, theranostics, cancer therapy, and optogenetics.Keywords: up-conversion nanoparticles, bioimaging, theranostics, therapy
format	article
author	Rostami I Rezvani Alanagh H Hu Z Shahmoradian SH
author_facet	Rostami I Rezvani Alanagh H Hu Z Shahmoradian SH
author_sort	Rostami I
title	Breakthroughs in medicine and bioimaging with up-conversion nanoparticles
title_short	Breakthroughs in medicine and bioimaging with up-conversion nanoparticles
title_full	Breakthroughs in medicine and bioimaging with up-conversion nanoparticles
title_fullStr	Breakthroughs in medicine and bioimaging with up-conversion nanoparticles
title_full_unstemmed	Breakthroughs in medicine and bioimaging with up-conversion nanoparticles
title_sort	breakthroughs in medicine and bioimaging with up-conversion nanoparticles
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/19452981c33644e3a2b1b95962cf45a9
work_keys_str_mv	AT rostamii breakthroughsinmedicineandbioimagingwithupconversionnanoparticles AT rezvanialanaghh breakthroughsinmedicineandbioimagingwithupconversionnanoparticles AT huz breakthroughsinmedicineandbioimagingwithupconversionnanoparticles AT shahmoradiansh breakthroughsinmedicineandbioimagingwithupconversionnanoparticles
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Breakthroughs in medicine and bioimaging with up-conversion nanoparticles

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