<named-content content-type="genus-species">Staphylococcus aureus</named-content> Protein A Promotes Immune Suppression

ABSTRACT Staphylococcus aureus is a prominent cause of human infections worldwide and is notorious for its ability to acquire resistance to antibiotics. Methicillin-resistant S. aureus (MRSA), in particular, is endemic in hospitals and is the most frequent cause of community-associated bacterial inf...

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Autores principales:	Scott D. Kobayashi, Frank R. DeLeo
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1945a76109fe494fb4f1a601707371ea
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spelling	oai:doaj.org-article:1945a76109fe494fb4f1a601707371ea2021-11-15T15:42:48Z<named-content content-type="genus-species">Staphylococcus aureus</named-content> Protein A Promotes Immune Suppression10.1128/mBio.00764-132150-7511https://doaj.org/article/1945a76109fe494fb4f1a601707371ea2013-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00764-13https://doaj.org/toc/2150-7511ABSTRACT Staphylococcus aureus is a prominent cause of human infections worldwide and is notorious for its ability to acquire resistance to antibiotics. Methicillin-resistant S. aureus (MRSA), in particular, is endemic in hospitals and is the most frequent cause of community-associated bacterial infections in the United States. Inasmuch as treatment options for severe MRSA infections are limited, there is need for a vaccine that protects against such infections. However, recent efforts to generate a staphylococcal vaccine have met with little success in human clinical trials. These failures are somewhat puzzling, since the vaccine antigens tested promote opsonophagocytosis in vitro and confer protection in animal infection models. One possibility is that the pathogen inhibits (and/or fails to elicit) the development of protective immunity in humans. Indeed, S. aureus produces numerous molecules that can potentially promote immune evasion, including protein A (SpA), an immunoglobulin (Ig)-binding protein present on the bacterial surface and freely secreted into the extracellular environment. SpA binds the Fc region of antibody and the Fab regions of the B-cell receptor, processes that are known to block opsonophagocytosis and cause B-cell death in vitro. In a recent study, Falugi et al. [F. Falugi, H. K. Kim, D. M. Missiakas, and O. Schneewind, mBio 4(5):e00575-13, 2013] showed that vaccination with spa mutant S. aureus strains lacking antibody Fc- and/or Fab-binding capacity protects against subsequent challenge with the USA300 epidemic strain. The findings provide strong support for the idea that SpA promotes S. aureus immune evasion in vivo and form the foundation for a new approach in our efforts to develop a vaccine that prevents severe S. aureus infections.Scott D. KobayashiFrank R. DeLeoAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 5 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Scott D. Kobayashi Frank R. DeLeo <named-content content-type="genus-species">Staphylococcus aureus</named-content> Protein A Promotes Immune Suppression
description	ABSTRACT Staphylococcus aureus is a prominent cause of human infections worldwide and is notorious for its ability to acquire resistance to antibiotics. Methicillin-resistant S. aureus (MRSA), in particular, is endemic in hospitals and is the most frequent cause of community-associated bacterial infections in the United States. Inasmuch as treatment options for severe MRSA infections are limited, there is need for a vaccine that protects against such infections. However, recent efforts to generate a staphylococcal vaccine have met with little success in human clinical trials. These failures are somewhat puzzling, since the vaccine antigens tested promote opsonophagocytosis in vitro and confer protection in animal infection models. One possibility is that the pathogen inhibits (and/or fails to elicit) the development of protective immunity in humans. Indeed, S. aureus produces numerous molecules that can potentially promote immune evasion, including protein A (SpA), an immunoglobulin (Ig)-binding protein present on the bacterial surface and freely secreted into the extracellular environment. SpA binds the Fc region of antibody and the Fab regions of the B-cell receptor, processes that are known to block opsonophagocytosis and cause B-cell death in vitro. In a recent study, Falugi et al. [F. Falugi, H. K. Kim, D. M. Missiakas, and O. Schneewind, mBio 4(5):e00575-13, 2013] showed that vaccination with spa mutant S. aureus strains lacking antibody Fc- and/or Fab-binding capacity protects against subsequent challenge with the USA300 epidemic strain. The findings provide strong support for the idea that SpA promotes S. aureus immune evasion in vivo and form the foundation for a new approach in our efforts to develop a vaccine that prevents severe S. aureus infections.
format	article
author	Scott D. Kobayashi Frank R. DeLeo
author_facet	Scott D. Kobayashi Frank R. DeLeo
author_sort	Scott D. Kobayashi
title	<named-content content-type="genus-species">Staphylococcus aureus</named-content> Protein A Promotes Immune Suppression
title_short	<named-content content-type="genus-species">Staphylococcus aureus</named-content> Protein A Promotes Immune Suppression
title_full	<named-content content-type="genus-species">Staphylococcus aureus</named-content> Protein A Promotes Immune Suppression
title_fullStr	<named-content content-type="genus-species">Staphylococcus aureus</named-content> Protein A Promotes Immune Suppression
title_full_unstemmed	<named-content content-type="genus-species">Staphylococcus aureus</named-content> Protein A Promotes Immune Suppression
title_sort	<named-content content-type="genus-species">staphylococcus aureus</named-content> protein a promotes immune suppression
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/1945a76109fe494fb4f1a601707371ea
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<named-content content-type="genus-species">Staphylococcus aureus</named-content> Protein A Promotes Immune Suppression

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