Psychological well-being in individuals with mild cognitive impairment

Nicola Gates,1–3 Michael Valenzuela,3 Perminder S Sachdev,1,2,4 Maria A Fiatarone Singh5,61School of Psychiatry, 2Centre for Healthy Brain Ageing (CheBA), University of New South Wales, Sydney, NSW, Australia; 3Regenerative Neuroscience Group, Brain and Mind Research Institute, University...

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Autores principales:	Gates N, Valenzuela M, Sachdev PS, Fiatarone Singh MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Quality of life wellbeing positive ageing mild cognitive impairment Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/1945e86cf4634dd4bddb383d3aab4028
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spelling	oai:doaj.org-article:1945e86cf4634dd4bddb383d3aab40282021-12-02T07:45:33ZPsychological well-being in individuals with mild cognitive impairment1178-1998https://doaj.org/article/1945e86cf4634dd4bddb383d3aab40282014-05-01T00:00:00Zhttps://www.dovepress.com/psychological-well-being-in-individuals-with-mild-cognitive-impairment-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Nicola Gates,1–3 Michael Valenzuela,3 Perminder S Sachdev,1,2,4 Maria A Fiatarone Singh5,61School of Psychiatry, 2Centre for Healthy Brain Ageing (CheBA), University of New South Wales, Sydney, NSW, Australia; 3Regenerative Neuroscience Group, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia; 4Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia; 5Exercise Health and Performance Faculty Research Group, Sydney Medical School, The University of Sydney, Lidcombe, NSW, Australia; 6Hebrew SeniorLife, Boston, MA, and Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USAObjectives: Cognitive impairments associated with aging and dementia are major sources of burden, deterioration in life quality, and reduced psychological well-being (PWB). Preventative measures to both reduce incident disease and improve PWB in those afflicted are increasingly targeting individuals with mild cognitive impairment (MCI) at early disease stage. However, there is very limited information regarding the relationships between early cognitive changes and memory concern, and life quality and PWB in adults with MCI; furthermore, PWB outcomes are too commonly overlooked in intervention trials. The purpose of this study was therefore to empirically test a theoretical model of PWB in MCI in order to inform clinical intervention.Methods: Baseline data from a convenience sample of 100 community-dwelling adults diagnosed with MCI enrolled in the Study of Mental Activity and Regular Training (SMART) trial were collected. A series of regression analyses were performed to develop a reduced model, then hierarchical regression with the Baron Kenny test of mediation derived the final three-tiered model of PWB.Results: Significant predictors of PWB were subjective memory concern, cognitive function, evaluations of quality of life, and negative affect, with a final model explaining 61% of the variance of PWB in MCI.Discussion: Our empirical findings support a theoretical tiered model of PWB in MCI and contribute to an understanding of the way in which early subtle cognitive deficits impact upon PWB. Multiple targets and entry points for clinical intervention were identified. These include improving the cognitive difficulties associated with MCI. Additionally, these highlight the importance of reducing memory concern, addressing low mood, and suggest that improving a person's quality of life may attenuate the negative effects of depression and anxiety on PWB in this cohort.Keywords: positive aging, quality of life, memory concernGates NValenzuela MSachdev PSFiatarone Singh MADove Medical PressarticleQuality of lifewellbeingpositive ageingmild cognitive impairmentGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 779-792 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Quality of life wellbeing positive ageing mild cognitive impairment Geriatrics RC952-954.6
spellingShingle	Quality of life wellbeing positive ageing mild cognitive impairment Geriatrics RC952-954.6 Gates N Valenzuela M Sachdev PS Fiatarone Singh MA Psychological well-being in individuals with mild cognitive impairment
description	Nicola Gates,1–3 Michael Valenzuela,3 Perminder S Sachdev,1,2,4 Maria A Fiatarone Singh5,61School of Psychiatry, 2Centre for Healthy Brain Ageing (CheBA), University of New South Wales, Sydney, NSW, Australia; 3Regenerative Neuroscience Group, Brain and Mind Research Institute, University of Sydney, Sydney, NSW, Australia; 4Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia; 5Exercise Health and Performance Faculty Research Group, Sydney Medical School, The University of Sydney, Lidcombe, NSW, Australia; 6Hebrew SeniorLife, Boston, MA, and Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USAObjectives: Cognitive impairments associated with aging and dementia are major sources of burden, deterioration in life quality, and reduced psychological well-being (PWB). Preventative measures to both reduce incident disease and improve PWB in those afflicted are increasingly targeting individuals with mild cognitive impairment (MCI) at early disease stage. However, there is very limited information regarding the relationships between early cognitive changes and memory concern, and life quality and PWB in adults with MCI; furthermore, PWB outcomes are too commonly overlooked in intervention trials. The purpose of this study was therefore to empirically test a theoretical model of PWB in MCI in order to inform clinical intervention.Methods: Baseline data from a convenience sample of 100 community-dwelling adults diagnosed with MCI enrolled in the Study of Mental Activity and Regular Training (SMART) trial were collected. A series of regression analyses were performed to develop a reduced model, then hierarchical regression with the Baron Kenny test of mediation derived the final three-tiered model of PWB.Results: Significant predictors of PWB were subjective memory concern, cognitive function, evaluations of quality of life, and negative affect, with a final model explaining 61% of the variance of PWB in MCI.Discussion: Our empirical findings support a theoretical tiered model of PWB in MCI and contribute to an understanding of the way in which early subtle cognitive deficits impact upon PWB. Multiple targets and entry points for clinical intervention were identified. These include improving the cognitive difficulties associated with MCI. Additionally, these highlight the importance of reducing memory concern, addressing low mood, and suggest that improving a person's quality of life may attenuate the negative effects of depression and anxiety on PWB in this cohort.Keywords: positive aging, quality of life, memory concern
format	article
author	Gates N Valenzuela M Sachdev PS Fiatarone Singh MA
author_facet	Gates N Valenzuela M Sachdev PS Fiatarone Singh MA
author_sort	Gates N
title	Psychological well-being in individuals with mild cognitive impairment
title_short	Psychological well-being in individuals with mild cognitive impairment
title_full	Psychological well-being in individuals with mild cognitive impairment
title_fullStr	Psychological well-being in individuals with mild cognitive impairment
title_full_unstemmed	Psychological well-being in individuals with mild cognitive impairment
title_sort	psychological well-being in individuals with mild cognitive impairment
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/1945e86cf4634dd4bddb383d3aab4028
work_keys_str_mv	AT gatesn psychologicalwellbeinginindividualswithmildcognitiveimpairment AT valenzuelam psychologicalwellbeinginindividualswithmildcognitiveimpairment AT sachdevps psychologicalwellbeinginindividualswithmildcognitiveimpairment AT fiataronesinghma psychologicalwellbeinginindividualswithmildcognitiveimpairment
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Psychological well-being in individuals with mild cognitive impairment

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