In vitro release of two anti-muscarinic drugs from soft contact lenses

Alex Hui,1 Magdalena Bajgrowicz-Cieslak,2 Chau-Minh Phan,3 Lyndon Jones3 1School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia; 2Department of Mechanics, Material Science and Engineering, Wroclaw University of Technology, Wroclaw, Poland; 3Centre for Contact Lens Research, Sc...

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Autores principales:	Hui A, Bajgrowicz-Cieslak M, Phan CM, Jones L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Contact Lens Drug Delivery Myopia Control Atropine Pirenzepine Multifocal Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1948f449e555435797e5b07d596bd9fd
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spelling	oai:doaj.org-article:1948f449e555435797e5b07d596bd9fd2021-12-02T04:05:49ZIn vitro release of two anti-muscarinic drugs from soft contact lenses1177-5483https://doaj.org/article/1948f449e555435797e5b07d596bd9fd2017-09-01T00:00:00Zhttps://www.dovepress.com/in-vitro-release-of-two-anti-muscarinic-drugs-from-soft-contact-lenses-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Alex Hui,1 Magdalena Bajgrowicz-Cieslak,2 Chau-Minh Phan,3 Lyndon Jones3 1School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia; 2Department of Mechanics, Material Science and Engineering, Wroclaw University of Technology, Wroclaw, Poland; 3Centre for Contact Lens Research, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON, Canada Abstract: The purpose of this study was to investigate the release of the anti-myopia drugs atropine sulfate and pirenzepine dihydrochloride from commercially available soft contact lenses. Standard ultraviolet (UV) absorbance–concentration curves were generated for atropine and pirenzepine. Ten commercially available contact lenses, including four multifocal lenses, were loaded by soaking in atropine or pirenzepine solutions at two different concentrations (10 mg/mL and 1 mg/mL). The release of the drugs into phosphate-buffered saline was determined over the course of 24 hours at 34°C using UV absorbance. Materials with surface charge released the greatest amount of atropine when loaded with either concentration when compared to the other lens types (p<0.05), releasing upward of 1.026±0.035 mg/lens and 0.979±0.024 mg/lens from etafilcon A and ocufilcon A, respectively. There were no significant differences in the amount of atropine or pirenzepine released from the multifocal and non-multifocal lenses made from the same lens materials. Narafilcon A material demonstrated prolonged release of up to 8 hours when loaded with pirenzepine, although the overall dose delivered from the lens into the solution was among the lowest of the materials investigated. The rest of the lenses reached a plateau within 2 hours of release, suggesting that they were unable to sustain drug release into the solution for long periods of time. Given that no single method of myopia control has yet shown itself to be completely effective in preventing myopia progression, a combination of optical and pharmaceutical devices comprising a drug delivering contact lens presents a novel solution that warrants further investigation. Keywords: contact lens, drug delivery, myopia control, atropine, pirenzepine, multifocal Hui ABajgrowicz-Cieslak MPhan CMJones LDove Medical PressarticleContact LensDrug DeliveryMyopia ControlAtropinePirenzepineMultifocalOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1657-1665 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Contact Lens Drug Delivery Myopia Control Atropine Pirenzepine Multifocal Ophthalmology RE1-994
spellingShingle	Contact Lens Drug Delivery Myopia Control Atropine Pirenzepine Multifocal Ophthalmology RE1-994 Hui A Bajgrowicz-Cieslak M Phan CM Jones L In vitro release of two anti-muscarinic drugs from soft contact lenses
description	Alex Hui,1 Magdalena Bajgrowicz-Cieslak,2 Chau-Minh Phan,3 Lyndon Jones3 1School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia; 2Department of Mechanics, Material Science and Engineering, Wroclaw University of Technology, Wroclaw, Poland; 3Centre for Contact Lens Research, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON, Canada Abstract: The purpose of this study was to investigate the release of the anti-myopia drugs atropine sulfate and pirenzepine dihydrochloride from commercially available soft contact lenses. Standard ultraviolet (UV) absorbance–concentration curves were generated for atropine and pirenzepine. Ten commercially available contact lenses, including four multifocal lenses, were loaded by soaking in atropine or pirenzepine solutions at two different concentrations (10 mg/mL and 1 mg/mL). The release of the drugs into phosphate-buffered saline was determined over the course of 24 hours at 34°C using UV absorbance. Materials with surface charge released the greatest amount of atropine when loaded with either concentration when compared to the other lens types (p<0.05), releasing upward of 1.026±0.035 mg/lens and 0.979±0.024 mg/lens from etafilcon A and ocufilcon A, respectively. There were no significant differences in the amount of atropine or pirenzepine released from the multifocal and non-multifocal lenses made from the same lens materials. Narafilcon A material demonstrated prolonged release of up to 8 hours when loaded with pirenzepine, although the overall dose delivered from the lens into the solution was among the lowest of the materials investigated. The rest of the lenses reached a plateau within 2 hours of release, suggesting that they were unable to sustain drug release into the solution for long periods of time. Given that no single method of myopia control has yet shown itself to be completely effective in preventing myopia progression, a combination of optical and pharmaceutical devices comprising a drug delivering contact lens presents a novel solution that warrants further investigation. Keywords: contact lens, drug delivery, myopia control, atropine, pirenzepine, multifocal
format	article
author	Hui A Bajgrowicz-Cieslak M Phan CM Jones L
author_facet	Hui A Bajgrowicz-Cieslak M Phan CM Jones L
author_sort	Hui A
title	In vitro release of two anti-muscarinic drugs from soft contact lenses
title_short	In vitro release of two anti-muscarinic drugs from soft contact lenses
title_full	In vitro release of two anti-muscarinic drugs from soft contact lenses
title_fullStr	In vitro release of two anti-muscarinic drugs from soft contact lenses
title_full_unstemmed	In vitro release of two anti-muscarinic drugs from soft contact lenses
title_sort	in vitro release of two anti-muscarinic drugs from soft contact lenses
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/1948f449e555435797e5b07d596bd9fd
work_keys_str_mv	AT huia invitroreleaseoftwoantimuscarinicdrugsfromsoftcontactlenses AT bajgrowiczcieslakm invitroreleaseoftwoantimuscarinicdrugsfromsoftcontactlenses AT phancm invitroreleaseoftwoantimuscarinicdrugsfromsoftcontactlenses AT jonesl invitroreleaseoftwoantimuscarinicdrugsfromsoftcontactlenses
_version_	1718401415319126016

In vitro release of two anti-muscarinic drugs from soft contact lenses

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