Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study

Introduction Childhood-onset schizophrenia with obsessive-compulsive symptoms (COSO) and without obsessive-compulsive symptoms (COS) share considerable overlap in clinical features and genetic risk factors. However, the extent of brain functional abnormalities in COSO and COS is poorly understood....

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Autores principales:	Yinghui Liang, Rongrong Shao, Zhiying Zhang, Xinmin Li, Longhao Zhou, Suqin Guo
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2018
Materias:	schizophrenia childhood alff compulsive amplitude of low-frequency fluctuation Medicine R
Acceso en línea:	https://doaj.org/article/194970dcf9bc4ba9ae1562d826a60b2c
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spelling	oai:doaj.org-article:194970dcf9bc4ba9ae1562d826a60b2c2021-12-02T18:39:09ZAmplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study1734-19221896-915110.5114/aoms.2018.73422https://doaj.org/article/194970dcf9bc4ba9ae1562d826a60b2c2018-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Amplitude-of-low-frequency-fluctuations-in-childhood-onset-schizophrenia-with-or,82935,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Childhood-onset schizophrenia with obsessive-compulsive symptoms (COSO) and without obsessive-compulsive symptoms (COS) share considerable overlap in clinical features and genetic risk factors. However, the extent of brain functional abnormalities in COSO and COS is poorly understood. Material and methods A total of 51 first-episode childhood schizophrenic patients and 30 healthy age- and sex-matched controls were recruited. We used the Yale-Brown Obsessive Compulsive Scale to divide patients into COSO (n = 21) and COS (n = 30) groups. Resting-state functional magnetic resonance imaging images were obtained using a gradient-echo echo-planar imaging sequence. Voxel-based analysis of amplitude of low-frequency fluctuation (ALFF) maps between the two groups was performed. Results The COS group showed significantly increased ALFF in the right caudate body, middle temporal gyrus and inferior parietal lobule (p < 0.05), while showing decreased ALFF in the left cerebellum posterior lobe (p < 0.05). The COSO group showed significantly increased ALFF in the left and right frontal lobe, cerebellum posterior lobe and precuneus (p < 0.05). When comparing the two groups, COSO showed significantly higher ALFF in the left cerebellum posterior lobe, frontal lobe, supramarginal gyrus, precuneus, right inferior frontal gyrus and medial frontal gyrus (p < 0.05). Interestingly, significantly lower ALFF was found in the right fusiform gyrus, corpus callosum and inferior parietal lobule in the group of patients with obsessive-compulsive symptoms (p < 0.05). Conclusions Our findings increase the understanding of the pathophysiology of schizophrenia and may provide imaging evidence for early diagnosis of COSO or COS.Yinghui LiangRongrong ShaoZhiying ZhangXinmin LiLonghao ZhouSuqin GuoTermedia Publishing Housearticleschizophreniachildhoodalffcompulsiveamplitude of low-frequency fluctuationchildhoodcompulsiveMedicineRENArchives of Medical Science, Vol 15, Iss 1, Pp 126-133 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia childhood alff compulsive amplitude of low-frequency fluctuation childhood compulsive Medicine R
spellingShingle	schizophrenia childhood alff compulsive amplitude of low-frequency fluctuation childhood compulsive Medicine R Yinghui Liang Rongrong Shao Zhiying Zhang Xinmin Li Longhao Zhou Suqin Guo Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study
description	Introduction Childhood-onset schizophrenia with obsessive-compulsive symptoms (COSO) and without obsessive-compulsive symptoms (COS) share considerable overlap in clinical features and genetic risk factors. However, the extent of brain functional abnormalities in COSO and COS is poorly understood. Material and methods A total of 51 first-episode childhood schizophrenic patients and 30 healthy age- and sex-matched controls were recruited. We used the Yale-Brown Obsessive Compulsive Scale to divide patients into COSO (n = 21) and COS (n = 30) groups. Resting-state functional magnetic resonance imaging images were obtained using a gradient-echo echo-planar imaging sequence. Voxel-based analysis of amplitude of low-frequency fluctuation (ALFF) maps between the two groups was performed. Results The COS group showed significantly increased ALFF in the right caudate body, middle temporal gyrus and inferior parietal lobule (p < 0.05), while showing decreased ALFF in the left cerebellum posterior lobe (p < 0.05). The COSO group showed significantly increased ALFF in the left and right frontal lobe, cerebellum posterior lobe and precuneus (p < 0.05). When comparing the two groups, COSO showed significantly higher ALFF in the left cerebellum posterior lobe, frontal lobe, supramarginal gyrus, precuneus, right inferior frontal gyrus and medial frontal gyrus (p < 0.05). Interestingly, significantly lower ALFF was found in the right fusiform gyrus, corpus callosum and inferior parietal lobule in the group of patients with obsessive-compulsive symptoms (p < 0.05). Conclusions Our findings increase the understanding of the pathophysiology of schizophrenia and may provide imaging evidence for early diagnosis of COSO or COS.
format	article
author	Yinghui Liang Rongrong Shao Zhiying Zhang Xinmin Li Longhao Zhou Suqin Guo
author_facet	Yinghui Liang Rongrong Shao Zhiying Zhang Xinmin Li Longhao Zhou Suqin Guo
author_sort	Yinghui Liang
title	Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study
title_short	Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study
title_full	Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study
title_fullStr	Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study
title_full_unstemmed	Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study
title_sort	amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study
publisher	Termedia Publishing House
publishDate	2018
url	https://doaj.org/article/194970dcf9bc4ba9ae1562d826a60b2c
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Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study

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