Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.

Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon t...

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Autores principales:	Oriol Mitjà, David Šmajs, Quique Bassat
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/194bbd8b0ac3496c93c35ce6840b1028
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spelling	oai:doaj.org-article:194bbd8b0ac3496c93c35ce6840b10282021-11-18T09:16:46ZAdvances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.1935-27271935-273510.1371/journal.pntd.0002283https://doaj.org/article/194bbd8b0ac3496c93c35ce6840b10282013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24205410/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manifestations and epidemiologic characteristics because the etiologic agents are indistinguishable in the laboratory. Serological tests are still considered standard laboratory methods for the diagnosis of endemic treponematoses and new rapid point-of-care treponemal tests have become available which are extremely useful in low-resource settings. In the past ten years, there has been an increasing effort to apply polymerase chain reaction to treponematoses and whole genome fingerprinting techniques have identified genetic signatures that can differentiate the existing treponemal strains; however, definitive diagnosis is also hampered by widespread unavailability of molecular diagnostics. We review the dilemmas in the diagnosis of endemic treponematoses, and advances in the discovery of new diagnostic tools.Oriol MitjàOriol MitjàDavid ŠmajsQuique BassatPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 7, Iss 10, p e2283 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Oriol Mitjà Oriol Mitjà David Šmajs Quique Bassat Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.
description	Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manifestations and epidemiologic characteristics because the etiologic agents are indistinguishable in the laboratory. Serological tests are still considered standard laboratory methods for the diagnosis of endemic treponematoses and new rapid point-of-care treponemal tests have become available which are extremely useful in low-resource settings. In the past ten years, there has been an increasing effort to apply polymerase chain reaction to treponematoses and whole genome fingerprinting techniques have identified genetic signatures that can differentiate the existing treponemal strains; however, definitive diagnosis is also hampered by widespread unavailability of molecular diagnostics. We review the dilemmas in the diagnosis of endemic treponematoses, and advances in the discovery of new diagnostic tools.
format	article
author	Oriol Mitjà Oriol Mitjà David Šmajs Quique Bassat
author_facet	Oriol Mitjà Oriol Mitjà David Šmajs Quique Bassat
author_sort	Oriol Mitjà
title	Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.
title_short	Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.
title_full	Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.
title_fullStr	Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.
title_full_unstemmed	Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.
title_sort	advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/194bbd8b0ac3496c93c35ce6840b1028
work_keys_str_mv	AT oriolmitja advancesinthediagnosisofendemictreponematosesyawsbejelandpinta AT oriolmitja advancesinthediagnosisofendemictreponematosesyawsbejelandpinta AT davidsmajs advancesinthediagnosisofendemictreponematosesyawsbejelandpinta AT quiquebassat advancesinthediagnosisofendemictreponematosesyawsbejelandpinta
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Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta.

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