Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study

Abstract Evidence from post-mortem, genetic, neuroimaging, and non-human animal research suggests that Major Depressive Disorder (MDD) is associated with abnormalities in brain myelin content. Brain regions implicated in this research, and in MDD more generally, include the nucleus accumbens (NAcc),...

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Autores principales:	Matthew D. Sacchet, Ian H. Gotlib
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/194ce9bbb7314a02a08f1657359eafc6
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spelling	oai:doaj.org-article:194ce9bbb7314a02a08f1657359eafc62021-12-02T15:06:09ZMyelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study10.1038/s41598-017-02062-y2045-2322https://doaj.org/article/194ce9bbb7314a02a08f1657359eafc62017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02062-yhttps://doaj.org/toc/2045-2322Abstract Evidence from post-mortem, genetic, neuroimaging, and non-human animal research suggests that Major Depressive Disorder (MDD) is associated with abnormalities in brain myelin content. Brain regions implicated in this research, and in MDD more generally, include the nucleus accumbens (NAcc), lateral prefrontal cortex (LPFC), insula, subgenual anterior cingulate cortex (sgACC), and medial prefrontal cortex (mPFC). We examined whether MDD is characterized by reduced myelin at the whole-brain level and in NAcc, LPFC, insula, sgACC, and mPFC. Quantitative magnetic resonance imaging (qMRI) permits the assessment of myelin content, in vivo, in the human brain through the measure of R1. In this study we used qMRI to measure R1 in 40 MDD and 40 healthy control (CTL) participants. We found that the MDD participants had lower levels of myelin than did the CTL participants at the whole-brain level and in the NAcc, and that myelin in the LPFC was reduced in MDD participants who had experienced a greater number of depressive episodes. Although further research is needed to elucidate the role of myelin in affecting emotional, cognitive, behavioral, and clinical aspects of MDD, the current study provides important new evidence that a fundamental property of brain composition, myelin, is altered in this disorder.Matthew D. SacchetIan H. GotlibNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Matthew D. Sacchet Ian H. Gotlib Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study
description	Abstract Evidence from post-mortem, genetic, neuroimaging, and non-human animal research suggests that Major Depressive Disorder (MDD) is associated with abnormalities in brain myelin content. Brain regions implicated in this research, and in MDD more generally, include the nucleus accumbens (NAcc), lateral prefrontal cortex (LPFC), insula, subgenual anterior cingulate cortex (sgACC), and medial prefrontal cortex (mPFC). We examined whether MDD is characterized by reduced myelin at the whole-brain level and in NAcc, LPFC, insula, sgACC, and mPFC. Quantitative magnetic resonance imaging (qMRI) permits the assessment of myelin content, in vivo, in the human brain through the measure of R1. In this study we used qMRI to measure R1 in 40 MDD and 40 healthy control (CTL) participants. We found that the MDD participants had lower levels of myelin than did the CTL participants at the whole-brain level and in the NAcc, and that myelin in the LPFC was reduced in MDD participants who had experienced a greater number of depressive episodes. Although further research is needed to elucidate the role of myelin in affecting emotional, cognitive, behavioral, and clinical aspects of MDD, the current study provides important new evidence that a fundamental property of brain composition, myelin, is altered in this disorder.
format	article
author	Matthew D. Sacchet Ian H. Gotlib
author_facet	Matthew D. Sacchet Ian H. Gotlib
author_sort	Matthew D. Sacchet
title	Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study
title_short	Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study
title_full	Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study
title_fullStr	Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study
title_full_unstemmed	Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study
title_sort	myelination of the brain in major depressive disorder: an in vivo quantitative magnetic resonance imaging study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/194ce9bbb7314a02a08f1657359eafc6
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_version_	1718388563466256384

Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study

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