Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression

The ability of cancer cells to survive in anchorage-independent conditions correlates with cancer aggressiveness. Here, by screening a human whole-genome shRNA library for the ability of osteosarcoma cells to form spheres in vitro, the authors identify a role for TMIGD3 isoform 1 in suppressing the...

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Autores principales:	Swathi V. Iyer, Atul Ranjan, Harold K. Elias, Alejandro Parrales, Hiromi Sasaki, Badal C. Roy, Shahid Umar, Ossama W. Tawfik, Tomoo Iwakuma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/19507a575f184165b6f54592493cb519
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spelling	oai:doaj.org-article:19507a575f184165b6f54592493cb5192021-12-02T17:32:35ZGenome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression10.1038/ncomms135612041-1723https://doaj.org/article/19507a575f184165b6f54592493cb5192016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13561https://doaj.org/toc/2041-1723The ability of cancer cells to survive in anchorage-independent conditions correlates with cancer aggressiveness. Here, by screening a human whole-genome shRNA library for the ability of osteosarcoma cells to form spheres in vitro, the authors identify a role for TMIGD3 isoform 1 in suppressing the metastatic potential of osteosarcoma.Swathi V. IyerAtul RanjanHarold K. EliasAlejandro ParralesHiromi SasakiBadal C. RoyShahid UmarOssama W. TawfikTomoo IwakumaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swathi V. Iyer Atul Ranjan Harold K. Elias Alejandro Parrales Hiromi Sasaki Badal C. Roy Shahid Umar Ossama W. Tawfik Tomoo Iwakuma Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression
description	The ability of cancer cells to survive in anchorage-independent conditions correlates with cancer aggressiveness. Here, by screening a human whole-genome shRNA library for the ability of osteosarcoma cells to form spheres in vitro, the authors identify a role for TMIGD3 isoform 1 in suppressing the metastatic potential of osteosarcoma.
format	article
author	Swathi V. Iyer Atul Ranjan Harold K. Elias Alejandro Parrales Hiromi Sasaki Badal C. Roy Shahid Umar Ossama W. Tawfik Tomoo Iwakuma
author_facet	Swathi V. Iyer Atul Ranjan Harold K. Elias Alejandro Parrales Hiromi Sasaki Badal C. Roy Shahid Umar Ossama W. Tawfik Tomoo Iwakuma
author_sort	Swathi V. Iyer
title	Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression
title_short	Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression
title_full	Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression
title_fullStr	Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression
title_full_unstemmed	Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression
title_sort	genome-wide rnai screening identifies tmigd3 isoform1 as a suppressor of nf-κb and osteosarcoma progression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/19507a575f184165b6f54592493cb519
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Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression

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