Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression

Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-κB and osteosarcoma progression

The ability of cancer cells to survive in anchorage-independent conditions correlates with cancer aggressiveness. Here, by screening a human whole-genome shRNA library for the ability of osteosarcoma cells to form spheres in vitro, the authors identify a role for TMIGD3 isoform 1 in suppressing the...

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Autores principales: Swathi V. Iyer, Atul Ranjan, Harold K. Elias, Alejandro Parrales, Hiromi Sasaki, Badal C. Roy, Shahid Umar, Ossama W. Tawfik, Tomoo Iwakuma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/19507a575f184165b6f54592493cb519
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