Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma

Abstract Targeting T-Cell Immunoreceptor with Ig and ITIM domain-poliovirus receptor (PVR) pathway is a potential therapeutic strategy in lung cancer. We analyzed the expression of PVR and programmed death ligand-1 (PD-L1) in surgically resected squamous cell lung carcinoma (SQCC) and determined its...

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Autores principales:	Jii Bum Lee, Min Hee Hong, Seong Yong Park, Sehyun Chae, Daehee Hwang, Sang-Jun Ha, Hyo Sup Shim, Hye Ryun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1950fc060d7d4609999c807a643ffd87
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spelling	oai:doaj.org-article:1950fc060d7d4609999c807a643ffd872021-12-02T13:39:29ZOverexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma10.1038/s41598-021-87624-x2045-2322https://doaj.org/article/1950fc060d7d4609999c807a643ffd872021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87624-xhttps://doaj.org/toc/2045-2322Abstract Targeting T-Cell Immunoreceptor with Ig and ITIM domain-poliovirus receptor (PVR) pathway is a potential therapeutic strategy in lung cancer. We analyzed the expression of PVR and programmed death ligand-1 (PD-L1) in surgically resected squamous cell lung carcinoma (SQCC) and determined its prognostic significance. We collected archival surgical specimens and data of 259 patients with SQCC at Yonsei Cancer Center (1998–2020). Analysis of variance was used to analyze the correlations between PVR and PD-L1 expression and patient characteristics. Kaplan–Meier curves were used to estimate recurrence-free survival (RFS) and overall survival (OS). Most patients were male (93%); the majority were diagnosed with stage 1 (47%), followed by stage 2 (29%) and stage 3 (21%). Overexpression of PVR resulted in a significantly shorter median RFS and OS (P = 0.01). PD-L1 expression was not significant in terms of prognosis. Patients were subdivided into four groups based on low and high PVR and PD-L1 expression. Those expressing high levels of PVR and PD-L1 had the shortest RFS (P = 0.03). PVR overexpression is associated with a poor prognosis in surgically resected SQCC. Inhibition of PVR as well as PD-L1 may help overcome the lack of response to immune checkpoint monotherapy.Jii Bum LeeMin Hee HongSeong Yong ParkSehyun ChaeDaehee HwangSang-Jun HaHyo Sup ShimHye Ryun KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jii Bum Lee Min Hee Hong Seong Yong Park Sehyun Chae Daehee Hwang Sang-Jun Ha Hyo Sup Shim Hye Ryun Kim Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma
description	Abstract Targeting T-Cell Immunoreceptor with Ig and ITIM domain-poliovirus receptor (PVR) pathway is a potential therapeutic strategy in lung cancer. We analyzed the expression of PVR and programmed death ligand-1 (PD-L1) in surgically resected squamous cell lung carcinoma (SQCC) and determined its prognostic significance. We collected archival surgical specimens and data of 259 patients with SQCC at Yonsei Cancer Center (1998–2020). Analysis of variance was used to analyze the correlations between PVR and PD-L1 expression and patient characteristics. Kaplan–Meier curves were used to estimate recurrence-free survival (RFS) and overall survival (OS). Most patients were male (93%); the majority were diagnosed with stage 1 (47%), followed by stage 2 (29%) and stage 3 (21%). Overexpression of PVR resulted in a significantly shorter median RFS and OS (P = 0.01). PD-L1 expression was not significant in terms of prognosis. Patients were subdivided into four groups based on low and high PVR and PD-L1 expression. Those expressing high levels of PVR and PD-L1 had the shortest RFS (P = 0.03). PVR overexpression is associated with a poor prognosis in surgically resected SQCC. Inhibition of PVR as well as PD-L1 may help overcome the lack of response to immune checkpoint monotherapy.
format	article
author	Jii Bum Lee Min Hee Hong Seong Yong Park Sehyun Chae Daehee Hwang Sang-Jun Ha Hyo Sup Shim Hye Ryun Kim
author_facet	Jii Bum Lee Min Hee Hong Seong Yong Park Sehyun Chae Daehee Hwang Sang-Jun Ha Hyo Sup Shim Hye Ryun Kim
author_sort	Jii Bum Lee
title	Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma
title_short	Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma
title_full	Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma
title_fullStr	Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma
title_full_unstemmed	Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma
title_sort	overexpression of pvr and pd-l1 and its association with prognosis in surgically resected squamous cell lung carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1950fc060d7d4609999c807a643ffd87
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Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma

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