Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing

Abstract Atopic dermatitis (AD) is a common and complex skin disorder, and the 5q22.1 region had been reported to be associated with AD. To confirm the susceptibility gene for AD in the 5q22.1 region by haplotype and targeted capture sequencing. The haplotypes were reconstructed with the genotyping...

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Autores principales:	Jie Zheng, Yuan-yuan Wu, Wen-liang Fang, Xin-ying Cai, Zeng-yun-ou Zhang, Chong-xian Yu, Xiao-dong Zheng, Feng-li Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1955b7caa5414170882cff79f8e14652
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spelling	oai:doaj.org-article:1955b7caa5414170882cff79f8e146522021-11-14T12:18:46ZConfirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing10.1038/s41598-021-01194-62045-2322https://doaj.org/article/1955b7caa5414170882cff79f8e146522021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01194-6https://doaj.org/toc/2045-2322Abstract Atopic dermatitis (AD) is a common and complex skin disorder, and the 5q22.1 region had been reported to be associated with AD. To confirm the susceptibility gene for AD in the 5q22.1 region by haplotype and targeted capture sequencing. The haplotypes were reconstructed with the genotyping data of four SNPs and six deletions from 3624 Chinese Hans AD patients and 5076 controls. The targeted capture sequencing spanning 5q22.1 region was performed in the selected samples. The gene level enrichment analysis was done using loss of function variants. A total of 62 haplotypes were found, and the H15 haplotype had the strongest association with AD (P = 3.92 × 10−10, OR 0.17, 95% CI 0.09–0.32). However, no co-segregation mutation sites were found in the sequencing analysis within the 16 selected samples, while the enrichment analysis indicated that TMEM232 was significantly associated with AD (P = 7.33 × 10–5, OR 0.33, 95% CI 0.19–0.58). This study confirms previous findings that the TMEM232 gene is associated with AD by haplotype analysis and targeted capture sequencing.Jie ZhengYuan-yuan WuWen-liang FangXin-ying CaiZeng-yun-ou ZhangChong-xian YuXiao-dong ZhengFeng-li XiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jie Zheng Yuan-yuan Wu Wen-liang Fang Xin-ying Cai Zeng-yun-ou Zhang Chong-xian Yu Xiao-dong Zheng Feng-li Xiao Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing
description	Abstract Atopic dermatitis (AD) is a common and complex skin disorder, and the 5q22.1 region had been reported to be associated with AD. To confirm the susceptibility gene for AD in the 5q22.1 region by haplotype and targeted capture sequencing. The haplotypes were reconstructed with the genotyping data of four SNPs and six deletions from 3624 Chinese Hans AD patients and 5076 controls. The targeted capture sequencing spanning 5q22.1 region was performed in the selected samples. The gene level enrichment analysis was done using loss of function variants. A total of 62 haplotypes were found, and the H15 haplotype had the strongest association with AD (P = 3.92 × 10−10, OR 0.17, 95% CI 0.09–0.32). However, no co-segregation mutation sites were found in the sequencing analysis within the 16 selected samples, while the enrichment analysis indicated that TMEM232 was significantly associated with AD (P = 7.33 × 10–5, OR 0.33, 95% CI 0.19–0.58). This study confirms previous findings that the TMEM232 gene is associated with AD by haplotype analysis and targeted capture sequencing.
format	article
author	Jie Zheng Yuan-yuan Wu Wen-liang Fang Xin-ying Cai Zeng-yun-ou Zhang Chong-xian Yu Xiao-dong Zheng Feng-li Xiao
author_facet	Jie Zheng Yuan-yuan Wu Wen-liang Fang Xin-ying Cai Zeng-yun-ou Zhang Chong-xian Yu Xiao-dong Zheng Feng-li Xiao
author_sort	Jie Zheng
title	Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing
title_short	Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing
title_full	Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing
title_fullStr	Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing
title_full_unstemmed	Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing
title_sort	confirming the tmem232 gene associated with atopic dermatitis through targeted capture sequencing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1955b7caa5414170882cff79f8e14652
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Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing

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