Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation

The browning of white adipose tissue has potential benefits on metabolic disorders, but the nutritional factors and neuronal signals that mediate browning remain incompletely understood. Here, the authors show that leucine deprivation can induce WAT browning via GCN2/ATF4 signaling in amygdalar PKC-...

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Autores principales:	Feixiang Yuan, Haizhou Jiang, Hanrui Yin, Xiaoxue Jiang, Fuxin Jiao, Shanghai Chen, Hao Ying, Yan Chen, Qiwei Zhai, Feifan Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/19563862b07e42079f5bbccb91a62d7e
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spelling	oai:doaj.org-article:19563862b07e42079f5bbccb91a62d7e2021-12-02T18:24:58ZActivation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation10.1038/s41467-020-16662-22041-1723https://doaj.org/article/19563862b07e42079f5bbccb91a62d7e2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16662-2https://doaj.org/toc/2041-1723The browning of white adipose tissue has potential benefits on metabolic disorders, but the nutritional factors and neuronal signals that mediate browning remain incompletely understood. Here, the authors show that leucine deprivation can induce WAT browning via GCN2/ATF4 signaling in amygdalar PKC-δ neurons.Feixiang YuanHaizhou JiangHanrui YinXiaoxue JiangFuxin JiaoShanghai ChenHao YingYan ChenQiwei ZhaiFeifan GuoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feixiang Yuan Haizhou Jiang Hanrui Yin Xiaoxue Jiang Fuxin Jiao Shanghai Chen Hao Ying Yan Chen Qiwei Zhai Feifan Guo Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation
description	The browning of white adipose tissue has potential benefits on metabolic disorders, but the nutritional factors and neuronal signals that mediate browning remain incompletely understood. Here, the authors show that leucine deprivation can induce WAT browning via GCN2/ATF4 signaling in amygdalar PKC-δ neurons.
format	article
author	Feixiang Yuan Haizhou Jiang Hanrui Yin Xiaoxue Jiang Fuxin Jiao Shanghai Chen Hao Ying Yan Chen Qiwei Zhai Feifan Guo
author_facet	Feixiang Yuan Haizhou Jiang Hanrui Yin Xiaoxue Jiang Fuxin Jiao Shanghai Chen Hao Ying Yan Chen Qiwei Zhai Feifan Guo
author_sort	Feixiang Yuan
title	Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation
title_short	Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation
title_full	Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation
title_fullStr	Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation
title_full_unstemmed	Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation
title_sort	activation of gcn2/atf4 signals in amygdalar pkc-δ neurons promotes wat browning under leucine deprivation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/19563862b07e42079f5bbccb91a62d7e
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Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation

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