The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6

The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6

Eukaryotic DNA replication is mediated by many proteins which are tightly regulated for an efficient firing of replication at each cell cycle. Here the authors report a cryo-EM structure of the yeast ORC–Cdc6 bound to an 85-bp ARS1 origin DNA revealing additional insights into how Cdc6 contributes t...

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Autores principales: Xiang Feng, Yasunori Noguchi, Marta Barbon, Bruce Stillman, Christian Speck, Huilin Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/19599113aefe4ae6ae2c2964f6d12947
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spelling oai:doaj.org-article:19599113aefe4ae6ae2c2964f6d129472021-12-02T17:12:24ZThe structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc610.1038/s41467-021-24199-12041-1723https://doaj.org/article/19599113aefe4ae6ae2c2964f6d129472021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24199-1https://doaj.org/toc/2041-1723Eukaryotic DNA replication is mediated by many proteins which are tightly regulated for an efficient firing of replication at each cell cycle. Here the authors report a cryo-EM structure of the yeast ORC–Cdc6 bound to an 85-bp ARS1 origin DNA revealing additional insights into how Cdc6 contributes to origin DNA recognition.Xiang FengYasunori NoguchiMarta BarbonBruce StillmanChristian SpeckHuilin LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiang Feng
Yasunori Noguchi
Marta Barbon
Bruce Stillman
Christian Speck
Huilin Li
The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6
description Eukaryotic DNA replication is mediated by many proteins which are tightly regulated for an efficient firing of replication at each cell cycle. Here the authors report a cryo-EM structure of the yeast ORC–Cdc6 bound to an 85-bp ARS1 origin DNA revealing additional insights into how Cdc6 contributes to origin DNA recognition.
format article
author Xiang Feng
Yasunori Noguchi
Marta Barbon
Bruce Stillman
Christian Speck
Huilin Li
author_facet Xiang Feng
Yasunori Noguchi
Marta Barbon
Bruce Stillman
Christian Speck
Huilin Li
author_sort Xiang Feng
title The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6
title_short The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6
title_full The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6
title_fullStr The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6
title_full_unstemmed The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6
title_sort structure of orc–cdc6 on an origin dna reveals the mechanism of orc activation by the replication initiator cdc6
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/19599113aefe4ae6ae2c2964f6d12947
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