Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, providing insights how Rab-GEF specificity is achieve...

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Main Authors:	Meredith L. Jenkins, Jean Piero Margaria, Jordan T. B. Stariha, Reece M. Hoffmann, Jacob A. McPhail, David J. Hamelin, Martin J. Boulanger, Emilio Hirsch, John E. Burke
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/195d660c5d9c4b958c577bebd6f5b073
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spelling	oai:doaj.org-article:195d660c5d9c4b958c577bebd6f5b0732021-12-02T16:50:08ZStructural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP510.1038/s41467-018-06196-z2041-1723https://doaj.org/article/195d660c5d9c4b958c577bebd6f5b0732018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06196-zhttps://doaj.org/toc/2041-1723Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, providing insights how Rab-GEF specificity is achieved.Meredith L. JenkinsJean Piero MargariaJordan T. B. StarihaReece M. HoffmannJacob A. McPhailDavid J. HamelinMartin J. BoulangerEmilio HirschJohn E. BurkeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meredith L. Jenkins Jean Piero Margaria Jordan T. B. Stariha Reece M. Hoffmann Jacob A. McPhail David J. Hamelin Martin J. Boulanger Emilio Hirsch John E. Burke Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
description	Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, providing insights how Rab-GEF specificity is achieved.
format	article
author	Meredith L. Jenkins Jean Piero Margaria Jordan T. B. Stariha Reece M. Hoffmann Jacob A. McPhail David J. Hamelin Martin J. Boulanger Emilio Hirsch John E. Burke
author_facet	Meredith L. Jenkins Jean Piero Margaria Jordan T. B. Stariha Reece M. Hoffmann Jacob A. McPhail David J. Hamelin Martin J. Boulanger Emilio Hirsch John E. Burke
author_sort	Meredith L. Jenkins
title	Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
title_short	Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
title_full	Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
title_fullStr	Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
title_full_unstemmed	Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
title_sort	structural determinants of rab11 activation by the guanine nucleotide exchange factor sh3bp5
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/195d660c5d9c4b958c577bebd6f5b073
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Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

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