Endometrial morphology in women of reproductive age with PCOS

Background. Polycystic ovary syndrome is the most common endocrine disease in women, affecting various aspects of health. The results of several studies indicate an increased prevalence of hyperplasia or endometrial cancer in women with PCOS, but there are no clinical recommendations on the need for...

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Autores principales:	E. M. Sharifulin, L. M. Lazareva, O. V. Kanya, A. A. Stefanenkova, D. V. Belykh, L. V. Suturina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	polycystic ovary syndrome endometrium chronic endometritis endometrial hyperplasia endometrial cancer Science Q
Acceso en línea:	https://doaj.org/article/1961674d2bbd4d69ad3f5b318d6e3f64
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spelling	oai:doaj.org-article:1961674d2bbd4d69ad3f5b318d6e3f642021-11-23T06:14:40ZEndometrial morphology in women of reproductive age with PCOS2541-94202587-959610.29413/ABS.2018-3.3.21https://doaj.org/article/1961674d2bbd4d69ad3f5b318d6e3f642018-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/597https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Polycystic ovary syndrome is the most common endocrine disease in women, affecting various aspects of health. The results of several studies indicate an increased prevalence of hyperplasia or endometrial cancer in women with PCOS, but there are no clinical recommendations on the need for assessing the endometrial condition in PCOS and approaches to predictions. Aim: to determine the frequency and structure of endometrial pathology among reproductive-aged patients with PCOS. Materials and methods. In a cross-sectional survey, we examined 1200 women who are subject to annual preventive examination. The research period was May - December 2017. The diagnosis of PCOS was made according to the consensus criteria adopted in May 2003 in Rotterdam. Participants signed informed consent for the survey. Results. We found 102 women with a verified diagnosis of PCOS. 56 of them completed their participation in the study; the median age was 32.19 ± 5.67 years. All patients underwent a biopsy of the endometrium with immunohistochemical examination. Features of the structure of the endometrium: a normal endometrial characteristic in 24 women (42.9 %), chronic endometritis -18 specimens (58.1 %), abnormal hypoplastic endometrium - 6 (19.4 %), simple endometrial hyperplasia -1 (3.2 %) adenocarcinoma -1 (3.2 %), proliferative endometrium with disorders - 7(22.6 %). Conclusions. In the examined women with PCOS there was a high incidence of histologically confirmed endometrial pathology, in the structure of which chronic endometritis predominates. The foregoing necessitates new research and development of clinical protocols for the timely detection of endometrial pathology in PCOS.E. M. SharifulinL. M. LazarevaO. V. KanyaA. A. StefanenkovaD. V. BelykhL. V. SuturinaScientific Сentre for Family Health and Human Reproduction Problemsarticlepolycystic ovary syndromeendometriumchronic endometritisendometrial hyperplasiaendometrial cancerScienceQRUActa Biomedica Scientifica, Vol 3, Iss 3, Pp 136-142 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	polycystic ovary syndrome endometrium chronic endometritis endometrial hyperplasia endometrial cancer Science Q
spellingShingle	polycystic ovary syndrome endometrium chronic endometritis endometrial hyperplasia endometrial cancer Science Q E. M. Sharifulin L. M. Lazareva O. V. Kanya A. A. Stefanenkova D. V. Belykh L. V. Suturina Endometrial morphology in women of reproductive age with PCOS
description	Background. Polycystic ovary syndrome is the most common endocrine disease in women, affecting various aspects of health. The results of several studies indicate an increased prevalence of hyperplasia or endometrial cancer in women with PCOS, but there are no clinical recommendations on the need for assessing the endometrial condition in PCOS and approaches to predictions. Aim: to determine the frequency and structure of endometrial pathology among reproductive-aged patients with PCOS. Materials and methods. In a cross-sectional survey, we examined 1200 women who are subject to annual preventive examination. The research period was May - December 2017. The diagnosis of PCOS was made according to the consensus criteria adopted in May 2003 in Rotterdam. Participants signed informed consent for the survey. Results. We found 102 women with a verified diagnosis of PCOS. 56 of them completed their participation in the study; the median age was 32.19 ± 5.67 years. All patients underwent a biopsy of the endometrium with immunohistochemical examination. Features of the structure of the endometrium: a normal endometrial characteristic in 24 women (42.9 %), chronic endometritis -18 specimens (58.1 %), abnormal hypoplastic endometrium - 6 (19.4 %), simple endometrial hyperplasia -1 (3.2 %) adenocarcinoma -1 (3.2 %), proliferative endometrium with disorders - 7(22.6 %). Conclusions. In the examined women with PCOS there was a high incidence of histologically confirmed endometrial pathology, in the structure of which chronic endometritis predominates. The foregoing necessitates new research and development of clinical protocols for the timely detection of endometrial pathology in PCOS.
format	article
author	E. M. Sharifulin L. M. Lazareva O. V. Kanya A. A. Stefanenkova D. V. Belykh L. V. Suturina
author_facet	E. M. Sharifulin L. M. Lazareva O. V. Kanya A. A. Stefanenkova D. V. Belykh L. V. Suturina
author_sort	E. M. Sharifulin
title	Endometrial morphology in women of reproductive age with PCOS
title_short	Endometrial morphology in women of reproductive age with PCOS
title_full	Endometrial morphology in women of reproductive age with PCOS
title_fullStr	Endometrial morphology in women of reproductive age with PCOS
title_full_unstemmed	Endometrial morphology in women of reproductive age with PCOS
title_sort	endometrial morphology in women of reproductive age with pcos
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/1961674d2bbd4d69ad3f5b318d6e3f64
work_keys_str_mv	AT emsharifulin endometrialmorphologyinwomenofreproductiveagewithpcos AT lmlazareva endometrialmorphologyinwomenofreproductiveagewithpcos AT ovkanya endometrialmorphologyinwomenofreproductiveagewithpcos AT aastefanenkova endometrialmorphologyinwomenofreproductiveagewithpcos AT dvbelykh endometrialmorphologyinwomenofreproductiveagewithpcos AT lvsuturina endometrialmorphologyinwomenofreproductiveagewithpcos
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Endometrial morphology in women of reproductive age with PCOS

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