Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients

Lan Li,1 Hui Dai,2 Jun Ke,2 Cen Shi,2 Nan Jiang,2 Chun-Mei Yang3 1Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 215006, People’s Republic of China; 2Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jia...

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Autores principales:	Li L, Dai H, Ke J, Shi C, Jiang N, Yang CM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	resting-state functional mri brain networks functional connection strength diabetic retinopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/19616f4404e44e1ab418e0b7c2c1fec1
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spelling	oai:doaj.org-article:19616f4404e44e1ab418e0b7c2c1fec12021-12-02T09:57:08ZResting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients1178-2021https://doaj.org/article/19616f4404e44e1ab418e0b7c2c1fec12019-12-01T00:00:00Zhttps://www.dovepress.com/resting-state-functional-mri-study-connection-strength-of-brain-networ-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lan Li,1 Hui Dai,2 Jun Ke,2 Cen Shi,2 Nan Jiang,2 Chun-Mei Yang3 1Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 215006, People’s Republic of China; 2Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of China; 3Department of Endocrinology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaCorrespondence: Hui DaiDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaTel/Fax +86512-67780633Email huizi198208@126.comChun-Mei YangDepartment of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaTel/Fax +86512-67780633Email muyi1979yang@163.comPurpose: To explore the functional connection strength (FCS) changes of brain networks in diabetic retinopathy (DR) patients and uncover the underlying mechanism.Methods and Materials: Twenty-one patients with DR and 21 age- and sex-matched healthy controls were enrolled from August 2012 to September 2014. Subjects were scanned using 3T MR with blood-oxygen-level dependent (BOLD) and 3-dimension fast spoiled gradient echo (3D-FSPGR) sequences. MR data was analyzed via preprocessing and functional network construction. After a group comparison, components of brain networks with significant group differences were extracted and the FCS of the brain network was evaluated. The brain areas were compared between patients and controls. P-values less than 0.05 were considered statistically significant. Connection strength was evaluated with alphasim, P<0.01.Results: The component maps of altered brain networks with quantified FCS were obtained in DR patients, demonstrating more disconnections mainly in the bilateral Heschl’s gyrus, left cuneus, left occipital lobe, bilateral amygdala, left parahippocampal, bilateral fusiform, and left superior parietal in the patients group compared to the healthy controls (P<0.01), while compensations may occur in the frontal-cingulum region, as well as among the right caudate, left thalamus, left inferior temporal lobe, and middle orbital frontal lobe.Conclusion: Brain network connections, decreased in the brain areas of which in charging with cognition and visual function, suggests that DR patients might have cognitive decline and visual function loss. However, there might be a frontal compensatory circle in patients with DR.Keywords: resting-state functional MRI, brain networks, functional connection strength, diabetic retinopathyLi LDai HKe JShi CJiang NYang CMDove Medical Pressarticleresting-state functional mribrain networksfunctional connection strengthdiabetic retinopathyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3359-3366 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	resting-state functional mri brain networks functional connection strength diabetic retinopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	resting-state functional mri brain networks functional connection strength diabetic retinopathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li L Dai H Ke J Shi C Jiang N Yang CM Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients
description	Lan Li,1 Hui Dai,2 Jun Ke,2 Cen Shi,2 Nan Jiang,2 Chun-Mei Yang3 1Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 215006, People’s Republic of China; 2Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of China; 3Department of Endocrinology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaCorrespondence: Hui DaiDepartment of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaTel/Fax +86512-67780633Email huizi198208@126.comChun-Mei YangDepartment of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, People’s Republic of ChinaTel/Fax +86512-67780633Email muyi1979yang@163.comPurpose: To explore the functional connection strength (FCS) changes of brain networks in diabetic retinopathy (DR) patients and uncover the underlying mechanism.Methods and Materials: Twenty-one patients with DR and 21 age- and sex-matched healthy controls were enrolled from August 2012 to September 2014. Subjects were scanned using 3T MR with blood-oxygen-level dependent (BOLD) and 3-dimension fast spoiled gradient echo (3D-FSPGR) sequences. MR data was analyzed via preprocessing and functional network construction. After a group comparison, components of brain networks with significant group differences were extracted and the FCS of the brain network was evaluated. The brain areas were compared between patients and controls. P-values less than 0.05 were considered statistically significant. Connection strength was evaluated with alphasim, P<0.01.Results: The component maps of altered brain networks with quantified FCS were obtained in DR patients, demonstrating more disconnections mainly in the bilateral Heschl’s gyrus, left cuneus, left occipital lobe, bilateral amygdala, left parahippocampal, bilateral fusiform, and left superior parietal in the patients group compared to the healthy controls (P<0.01), while compensations may occur in the frontal-cingulum region, as well as among the right caudate, left thalamus, left inferior temporal lobe, and middle orbital frontal lobe.Conclusion: Brain network connections, decreased in the brain areas of which in charging with cognition and visual function, suggests that DR patients might have cognitive decline and visual function loss. However, there might be a frontal compensatory circle in patients with DR.Keywords: resting-state functional MRI, brain networks, functional connection strength, diabetic retinopathy
format	article
author	Li L Dai H Ke J Shi C Jiang N Yang CM
author_facet	Li L Dai H Ke J Shi C Jiang N Yang CM
author_sort	Li L
title	Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients
title_short	Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients
title_full	Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients
title_fullStr	Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients
title_full_unstemmed	Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients
title_sort	resting-state functional mri study: connection strength of brain networks in dr patients
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/19616f4404e44e1ab418e0b7c2c1fec1
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_version_	1718397870476886016

Resting-State Functional MRI Study: Connection Strength of Brain Networks in DR Patients

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