L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force

L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force

L1 is a group of active retrotransposons in humans. Here the authors show that m6A modifications on L1 RNA increase translation efficiency and retrotransposition in human cells. M6A motifs are more enriched in evolutionary young L1s.

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Auteurs principaux: Sung-Yeon Hwang, Hyunchul Jung, Seyoung Mun, Sungwon Lee, Kiwon Park, S. Chan Baek, Hyungseok C. Moon, Hyewon Kim, Baekgyu Kim, Yongkuk Choi, Young-Hyun Go, Wanxiangfu Tang, Jongsu Choi, Jung Kyoon Choi, Hyuk-Jin Cha, Hye Yoon Park, Ping Liang, V. Narry Kim, Kyudong Han, Kwangseog Ahn
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/1961d00465714c29a8b1bed8e65a3309
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Résumé:L1 is a group of active retrotransposons in humans. Here the authors show that m6A modifications on L1 RNA increase translation efficiency and retrotransposition in human cells. M6A motifs are more enriched in evolutionary young L1s.

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