L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force

L1 is a group of active retrotransposons in humans. Here the authors show that m6A modifications on L1 RNA increase translation efficiency and retrotransposition in human cells. M6A motifs are more enriched in evolutionary young L1s.

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Autores principales:	Sung-Yeon Hwang, Hyunchul Jung, Seyoung Mun, Sungwon Lee, Kiwon Park, S. Chan Baek, Hyungseok C. Moon, Hyewon Kim, Baekgyu Kim, Yongkuk Choi, Young-Hyun Go, Wanxiangfu Tang, Jongsu Choi, Jung Kyoon Choi, Hyuk-Jin Cha, Hye Yoon Park, Ping Liang, V. Narry Kim, Kyudong Han, Kwangseog Ahn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1961d00465714c29a8b1bed8e65a3309
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spelling	oai:doaj.org-article:1961d00465714c29a8b1bed8e65a33092021-12-02T13:30:25ZL1 retrotransposons exploit RNA m6A modification as an evolutionary driving force10.1038/s41467-021-21197-12041-1723https://doaj.org/article/1961d00465714c29a8b1bed8e65a33092021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21197-1https://doaj.org/toc/2041-1723L1 is a group of active retrotransposons in humans. Here the authors show that m6A modifications on L1 RNA increase translation efficiency and retrotransposition in human cells. M6A motifs are more enriched in evolutionary young L1s.Sung-Yeon HwangHyunchul JungSeyoung MunSungwon LeeKiwon ParkS. Chan BaekHyungseok C. MoonHyewon KimBaekgyu KimYongkuk ChoiYoung-Hyun GoWanxiangfu TangJongsu ChoiJung Kyoon ChoiHyuk-Jin ChaHye Yoon ParkPing LiangV. Narry KimKyudong HanKwangseog AhnNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sung-Yeon Hwang Hyunchul Jung Seyoung Mun Sungwon Lee Kiwon Park S. Chan Baek Hyungseok C. Moon Hyewon Kim Baekgyu Kim Yongkuk Choi Young-Hyun Go Wanxiangfu Tang Jongsu Choi Jung Kyoon Choi Hyuk-Jin Cha Hye Yoon Park Ping Liang V. Narry Kim Kyudong Han Kwangseog Ahn L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
description	L1 is a group of active retrotransposons in humans. Here the authors show that m6A modifications on L1 RNA increase translation efficiency and retrotransposition in human cells. M6A motifs are more enriched in evolutionary young L1s.
format	article
author	Sung-Yeon Hwang Hyunchul Jung Seyoung Mun Sungwon Lee Kiwon Park S. Chan Baek Hyungseok C. Moon Hyewon Kim Baekgyu Kim Yongkuk Choi Young-Hyun Go Wanxiangfu Tang Jongsu Choi Jung Kyoon Choi Hyuk-Jin Cha Hye Yoon Park Ping Liang V. Narry Kim Kyudong Han Kwangseog Ahn
author_facet	Sung-Yeon Hwang Hyunchul Jung Seyoung Mun Sungwon Lee Kiwon Park S. Chan Baek Hyungseok C. Moon Hyewon Kim Baekgyu Kim Yongkuk Choi Young-Hyun Go Wanxiangfu Tang Jongsu Choi Jung Kyoon Choi Hyuk-Jin Cha Hye Yoon Park Ping Liang V. Narry Kim Kyudong Han Kwangseog Ahn
author_sort	Sung-Yeon Hwang
title	L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
title_short	L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
title_full	L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
title_fullStr	L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
title_full_unstemmed	L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
title_sort	l1 retrotransposons exploit rna m6a modification as an evolutionary driving force
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1961d00465714c29a8b1bed8e65a3309
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L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force

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