Tea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro

Tea polyphenols (TP) are the main active components of tea. In our study, the effect of TP on the menopause and aging related memory decline and the mechanisms focused on the brain glucose metabolism were clarified. In vivo, ovariectomy (OVX) combined with D-galactose (D-gal) injection were used to...

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Autores principales:	Luping Zhang, Mengqian Shi, Chenmeng Song, Le Cheng, Xuemin Li, Qian Yang, Yusen Zhang, Ruirui Dong, Jie Kou, Chenhui Lv, Lili Wang, Haifeng Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Aging Ovariectomy Tea polyphenols Glucose metabolism OCR ECAR Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/1965b8314cf74fdfbbc4c01efb67da20
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spelling	oai:doaj.org-article:1965b8314cf74fdfbbc4c01efb67da202021-11-18T04:46:20ZTea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro1756-464610.1016/j.jff.2021.104856https://doaj.org/article/1965b8314cf74fdfbbc4c01efb67da202021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621005053https://doaj.org/toc/1756-4646Tea polyphenols (TP) are the main active components of tea. In our study, the effect of TP on the menopause and aging related memory decline and the mechanisms focused on the brain glucose metabolism were clarified. In vivo, ovariectomy (OVX) combined with D-galactose (D-gal) injection were used to establish the memory decline model. TP administration improved the spatial memory by increasing the expressions of GLUT1, 3 and Tau protein O-GlcNAc glycosylation, decreasing Tau hyper-phosphorylation and the Aβ1-42 level, and improving the morphology of mitochondria in hippocampus. Furthermore, in vitro, PC12 cells were treated with Aβ1-42 and EGCG treatment regulated the mitochondrial respiratory function and glycolytic functions, improved the activities of the key enzymes in glycolysis and tricarboxylic acid cycle, increased the SOD activity and decreased the MDA levels in cells. Our study suggests that TP improve the memory in aging ovariectomized rats by regulating brain glucose metabolism.Luping ZhangMengqian ShiChenmeng SongLe ChengXuemin LiQian YangYusen ZhangRuirui DongJie KouChenhui LvLili WangHaifeng ZhaoElsevierarticleAgingOvariectomyTea polyphenolsGlucose metabolismOCRECARNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104856- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aging Ovariectomy Tea polyphenols Glucose metabolism OCR ECAR Nutrition. Foods and food supply TX341-641
spellingShingle	Aging Ovariectomy Tea polyphenols Glucose metabolism OCR ECAR Nutrition. Foods and food supply TX341-641 Luping Zhang Mengqian Shi Chenmeng Song Le Cheng Xuemin Li Qian Yang Yusen Zhang Ruirui Dong Jie Kou Chenhui Lv Lili Wang Haifeng Zhao Tea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro
description	Tea polyphenols (TP) are the main active components of tea. In our study, the effect of TP on the menopause and aging related memory decline and the mechanisms focused on the brain glucose metabolism were clarified. In vivo, ovariectomy (OVX) combined with D-galactose (D-gal) injection were used to establish the memory decline model. TP administration improved the spatial memory by increasing the expressions of GLUT1, 3 and Tau protein O-GlcNAc glycosylation, decreasing Tau hyper-phosphorylation and the Aβ1-42 level, and improving the morphology of mitochondria in hippocampus. Furthermore, in vitro, PC12 cells were treated with Aβ1-42 and EGCG treatment regulated the mitochondrial respiratory function and glycolytic functions, improved the activities of the key enzymes in glycolysis and tricarboxylic acid cycle, increased the SOD activity and decreased the MDA levels in cells. Our study suggests that TP improve the memory in aging ovariectomized rats by regulating brain glucose metabolism.
format	article
author	Luping Zhang Mengqian Shi Chenmeng Song Le Cheng Xuemin Li Qian Yang Yusen Zhang Ruirui Dong Jie Kou Chenhui Lv Lili Wang Haifeng Zhao
author_facet	Luping Zhang Mengqian Shi Chenmeng Song Le Cheng Xuemin Li Qian Yang Yusen Zhang Ruirui Dong Jie Kou Chenhui Lv Lili Wang Haifeng Zhao
author_sort	Luping Zhang
title	Tea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro
title_short	Tea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro
title_full	Tea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro
title_fullStr	Tea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro
title_full_unstemmed	Tea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro
title_sort	tea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1965b8314cf74fdfbbc4c01efb67da20
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Tea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro

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