Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats

Abstract Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the development and maintenance of addiction. Rodent studies suggest that this sensitivity is related, in part, to the propensity to attribute incentive salience to food cues, which, in turn, contributes to...

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Autores principales:	Christopher P. King, Jordan A. Tripi, Alesa R. Hughson, Aidan P. Horvath, Alexander C. Lamparelli, Katie L. Holl, Apurva S. Chitre, Oksana Polesskaya, Keita Ishiwari, Leah C. Solberg Woods, Abraham A. Palmer, Terry E. Robinson, Shelly B. Flagel, Paul J. Meyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1966665f7b7c41679e07bd86e26a9015
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spelling	oai:doaj.org-article:1966665f7b7c41679e07bd86e26a90152021-12-02T13:23:50ZSensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats10.1038/s41598-020-80798-w2045-2322https://doaj.org/article/1966665f7b7c41679e07bd86e26a90152021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80798-whttps://doaj.org/toc/2045-2322Abstract Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the development and maintenance of addiction. Rodent studies suggest that this sensitivity is related, in part, to the propensity to attribute incentive salience to food cues, which, in turn, contributes to the maintenance of cocaine self-administration, and cue-induced relapse of drug-seeking. Whereas each of these traits has established links to drug use, the relatedness between the individual traits themselves has not been well characterized in preclinical models. To this end, the propensity to attribute incentive salience to a food cue was first assessed in two distinct cohorts of 2716 outbred heterogeneous stock rats (HS; formerly N:NIH). We then determined whether each cohort was associated with performance in one of two paradigms (cocaine conditioned cue preference and cocaine contextual conditioning). These measure the unconditioned locomotor effects of cocaine, as well as conditioned approach and the locomotor response to a cocaine-paired floor or context. There was large individual variability and sex differences among all traits, but they were largely independent of one another in both males and females. These findings suggest that these traits may contribute to drug-use via independent underlying neuropsychological processes.Christopher P. KingJordan A. TripiAlesa R. HughsonAidan P. HorvathAlexander C. LamparelliKatie L. HollApurva S. ChitreOksana PolesskayaKeita IshiwariLeah C. Solberg WoodsAbraham A. PalmerTerry E. RobinsonShelly B. FlagelPaul J. MeyerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christopher P. King Jordan A. Tripi Alesa R. Hughson Aidan P. Horvath Alexander C. Lamparelli Katie L. Holl Apurva S. Chitre Oksana Polesskaya Keita Ishiwari Leah C. Solberg Woods Abraham A. Palmer Terry E. Robinson Shelly B. Flagel Paul J. Meyer Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
description	Abstract Sensitivity to cocaine and its associated stimuli (“cues”) are important factors in the development and maintenance of addiction. Rodent studies suggest that this sensitivity is related, in part, to the propensity to attribute incentive salience to food cues, which, in turn, contributes to the maintenance of cocaine self-administration, and cue-induced relapse of drug-seeking. Whereas each of these traits has established links to drug use, the relatedness between the individual traits themselves has not been well characterized in preclinical models. To this end, the propensity to attribute incentive salience to a food cue was first assessed in two distinct cohorts of 2716 outbred heterogeneous stock rats (HS; formerly N:NIH). We then determined whether each cohort was associated with performance in one of two paradigms (cocaine conditioned cue preference and cocaine contextual conditioning). These measure the unconditioned locomotor effects of cocaine, as well as conditioned approach and the locomotor response to a cocaine-paired floor or context. There was large individual variability and sex differences among all traits, but they were largely independent of one another in both males and females. These findings suggest that these traits may contribute to drug-use via independent underlying neuropsychological processes.
format	article
author	Christopher P. King Jordan A. Tripi Alesa R. Hughson Aidan P. Horvath Alexander C. Lamparelli Katie L. Holl Apurva S. Chitre Oksana Polesskaya Keita Ishiwari Leah C. Solberg Woods Abraham A. Palmer Terry E. Robinson Shelly B. Flagel Paul J. Meyer
author_facet	Christopher P. King Jordan A. Tripi Alesa R. Hughson Aidan P. Horvath Alexander C. Lamparelli Katie L. Holl Apurva S. Chitre Oksana Polesskaya Keita Ishiwari Leah C. Solberg Woods Abraham A. Palmer Terry E. Robinson Shelly B. Flagel Paul J. Meyer
author_sort	Christopher P. King
title	Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
title_short	Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
title_full	Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
title_fullStr	Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
title_full_unstemmed	Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
title_sort	sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1966665f7b7c41679e07bd86e26a9015
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Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats

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