Environmentally relevant concentrations of arsenic induces apoptosis in the early life stage of zebrafish
Arsenic (As) in the aquatic environment is a considerable environmental issue, previous studies have reported the toxic effects of low concentrations (≤ 150 μg/L) of As on fish. However, limited information is available regarding the impact of low levels of As on apoptosis. To evaluate this, zebrafi...
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2021
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oai:doaj.org-article:1970bb89868f46eea44eb442af9520832021-11-06T04:14:33ZEnvironmentally relevant concentrations of arsenic induces apoptosis in the early life stage of zebrafish0147-651310.1016/j.ecoenv.2021.112883https://doaj.org/article/1970bb89868f46eea44eb442af9520832021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321009957https://doaj.org/toc/0147-6513Arsenic (As) in the aquatic environment is a considerable environmental issue, previous studies have reported the toxic effects of low concentrations (≤ 150 μg/L) of As on fish. However, limited information is available regarding the impact of low levels of As on apoptosis. To evaluate this, zebrafish embryos were exposed to different concentrations (0, 25, 50, 75, and 150 μg/L) of As (arsenite [AsIII] and arsenate [AsV]) for 120 h. Our results indicated that low concentrations of AsIII exposure significantly inhibited the survival of zebrafish larvae, and significantly increased the transcription of Caspase-9 and Caspase-3, the ratio of Bax/Bcl-2 transcription, and protein levels of Caspase-3. In contrast, AsV decreased the ratios of Bax/Bcl-2 transcription and protein levels, as well as protein levels of Caspase-3. Our data demonstrated that AsIII and AsV exert different toxic effects, AsIII induced apoptosis via the mitochondrial pathway and the extrinsic pathway, while AsV induced apoptosis only via the mitochondrial pathway.Wen-Jun ZhaoXiang LiZe-Qiong XuKe-Ming FangHua-Chang HongHong-Jie SunDong-Xing GuanXin-Wei YuElsevierarticleEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 227, Iss , Pp 112883- (2021) |
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DOAJ |
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EN |
| topic |
Environmental pollution TD172-193.5 Environmental sciences GE1-350 |
| spellingShingle |
Environmental pollution TD172-193.5 Environmental sciences GE1-350 Wen-Jun Zhao Xiang Li Ze-Qiong Xu Ke-Ming Fang Hua-Chang Hong Hong-Jie Sun Dong-Xing Guan Xin-Wei Yu Environmentally relevant concentrations of arsenic induces apoptosis in the early life stage of zebrafish |
| description |
Arsenic (As) in the aquatic environment is a considerable environmental issue, previous studies have reported the toxic effects of low concentrations (≤ 150 μg/L) of As on fish. However, limited information is available regarding the impact of low levels of As on apoptosis. To evaluate this, zebrafish embryos were exposed to different concentrations (0, 25, 50, 75, and 150 μg/L) of As (arsenite [AsIII] and arsenate [AsV]) for 120 h. Our results indicated that low concentrations of AsIII exposure significantly inhibited the survival of zebrafish larvae, and significantly increased the transcription of Caspase-9 and Caspase-3, the ratio of Bax/Bcl-2 transcription, and protein levels of Caspase-3. In contrast, AsV decreased the ratios of Bax/Bcl-2 transcription and protein levels, as well as protein levels of Caspase-3. Our data demonstrated that AsIII and AsV exert different toxic effects, AsIII induced apoptosis via the mitochondrial pathway and the extrinsic pathway, while AsV induced apoptosis only via the mitochondrial pathway. |
| format |
article |
| author |
Wen-Jun Zhao Xiang Li Ze-Qiong Xu Ke-Ming Fang Hua-Chang Hong Hong-Jie Sun Dong-Xing Guan Xin-Wei Yu |
| author_facet |
Wen-Jun Zhao Xiang Li Ze-Qiong Xu Ke-Ming Fang Hua-Chang Hong Hong-Jie Sun Dong-Xing Guan Xin-Wei Yu |
| author_sort |
Wen-Jun Zhao |
| title |
Environmentally relevant concentrations of arsenic induces apoptosis in the early life stage of zebrafish |
| title_short |
Environmentally relevant concentrations of arsenic induces apoptosis in the early life stage of zebrafish |
| title_full |
Environmentally relevant concentrations of arsenic induces apoptosis in the early life stage of zebrafish |
| title_fullStr |
Environmentally relevant concentrations of arsenic induces apoptosis in the early life stage of zebrafish |
| title_full_unstemmed |
Environmentally relevant concentrations of arsenic induces apoptosis in the early life stage of zebrafish |
| title_sort |
environmentally relevant concentrations of arsenic induces apoptosis in the early life stage of zebrafish |
| publisher |
Elsevier |
| publishDate |
2021 |
| url |
https://doaj.org/article/1970bb89868f46eea44eb442af952083 |
| work_keys_str_mv |
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1718443901665148928 |