Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders

α-synuclein is considered the main pathological protein in a variety of neurodegenerative disorders, such as Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies. As of now, numerous studies have been aimed at examining the post-translational modifications of α-synuclein to de...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Frank Y. Shan, Kar-Ming Fung, Tarek Zieneldien, Janice Kim, Chuanhai Cao, Jason H. Huang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Parkinson’s disease Lewy body dopamine substantia nigra synucleinopathy post-translational modifications Science Q
Acceso en línea:	https://doaj.org/article/19740ac3ef7249608ed5dbb1dd16cc78
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:19740ac3ef7249608ed5dbb1dd16cc78
record_format	dspace
spelling	oai:doaj.org-article:19740ac3ef7249608ed5dbb1dd16cc782021-11-25T18:10:29ZExamining the Toxicity of α-Synuclein in Neurodegenerative Disorders10.3390/life111111262075-1729https://doaj.org/article/19740ac3ef7249608ed5dbb1dd16cc782021-10-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1126https://doaj.org/toc/2075-1729α-synuclein is considered the main pathological protein in a variety of neurodegenerative disorders, such as Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies. As of now, numerous studies have been aimed at examining the post-translational modifications of α-synuclein to determine their effects on α-synuclein aggregation, propagation, and oligomerization, as well as the potential cellular pathway dysfunctions caused by α-synuclein, to determine the role of the protein in disease progression. Furthermore, α-synuclein also appears to contribute to the fibrilization of tau and amyloid beta, which are crucial proteins in Alzheimer’s disease, advocating for α-synuclein’s preeminent role in neurodegeneration. Due to this, investigating the mechanisms of toxicity of α-synuclein in neurodegeneration may lead to a more proficient understanding of the timeline progression in neurodegenerative synucleinopathies and could thereby lead to the development of potent targeted therapies.Frank Y. ShanKar-Ming FungTarek ZieneldienJanice KimChuanhai CaoJason H. HuangMDPI AGarticleParkinson’s diseaseLewy bodydopaminesubstantia nigrasynucleinopathypost-translational modificationsScienceQENLife, Vol 11, Iss 1126, p 1126 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease Lewy body dopamine substantia nigra synucleinopathy post-translational modifications Science Q
spellingShingle	Parkinson’s disease Lewy body dopamine substantia nigra synucleinopathy post-translational modifications Science Q Frank Y. Shan Kar-Ming Fung Tarek Zieneldien Janice Kim Chuanhai Cao Jason H. Huang Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders
description	α-synuclein is considered the main pathological protein in a variety of neurodegenerative disorders, such as Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies. As of now, numerous studies have been aimed at examining the post-translational modifications of α-synuclein to determine their effects on α-synuclein aggregation, propagation, and oligomerization, as well as the potential cellular pathway dysfunctions caused by α-synuclein, to determine the role of the protein in disease progression. Furthermore, α-synuclein also appears to contribute to the fibrilization of tau and amyloid beta, which are crucial proteins in Alzheimer’s disease, advocating for α-synuclein’s preeminent role in neurodegeneration. Due to this, investigating the mechanisms of toxicity of α-synuclein in neurodegeneration may lead to a more proficient understanding of the timeline progression in neurodegenerative synucleinopathies and could thereby lead to the development of potent targeted therapies.
format	article
author	Frank Y. Shan Kar-Ming Fung Tarek Zieneldien Janice Kim Chuanhai Cao Jason H. Huang
author_facet	Frank Y. Shan Kar-Ming Fung Tarek Zieneldien Janice Kim Chuanhai Cao Jason H. Huang
author_sort	Frank Y. Shan
title	Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders
title_short	Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders
title_full	Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders
title_fullStr	Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders
title_full_unstemmed	Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders
title_sort	examining the toxicity of α-synuclein in neurodegenerative disorders
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/19740ac3ef7249608ed5dbb1dd16cc78
work_keys_str_mv	AT frankyshan examiningthetoxicityofasynucleininneurodegenerativedisorders AT karmingfung examiningthetoxicityofasynucleininneurodegenerativedisorders AT tarekzieneldien examiningthetoxicityofasynucleininneurodegenerativedisorders AT janicekim examiningthetoxicityofasynucleininneurodegenerativedisorders AT chuanhaicao examiningthetoxicityofasynucleininneurodegenerativedisorders AT jasonhhuang examiningthetoxicityofasynucleininneurodegenerativedisorders
_version_	1718411483973419008

Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders

Ejemplares similares