Modern principles of atherogenic dyslipidemia management in special groups of patients

Aim.To provide modern view on atherogenic disorders in the blood lipid spectrum, the principles of lipid-lowering therapy prescription in certain groups of patients, the safety issues of statin therapy in patients with chronic liver diseases. Materials and methods.The data of 55 scientific source...

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Autores principales:	Marina G. Bubnova, Lev E. Parnes
Formato:	article
Lenguaje:	EN RU
Publicado:	Concilium Medicum 2020
Materias:	dyslipidemia atherosclerosis statins chronic liver diseases hepatoprotectors Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/197447f5eafe4ae5877e61437824d9c4
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spelling	oai:doaj.org-article:197447f5eafe4ae5877e61437824d9c42021-12-01T22:07:01ZModern principles of atherogenic dyslipidemia management in special groups of patients2221-71852658-570710.26442/22217185.2020.1.200089https://doaj.org/article/197447f5eafe4ae5877e61437824d9c42020-09-01T00:00:00Zhttps://cardiosomatics.orscience.ru/2221-7185/article/viewFile/46034/31037https://doaj.org/toc/2221-7185https://doaj.org/toc/2658-5707Aim.To provide modern view on atherogenic disorders in the blood lipid spectrum, the principles of lipid-lowering therapy prescription in certain groups of patients, the safety issues of statin therapy in patients with chronic liver diseases. Materials and methods.The data of 55 scientific sources published in the Russian and foreign press in 19882020 were analyzed. Results.It is known that atherogenic dyslipidemia is a key factor in pathogenesis of atherosclerotic cardiovascular diseases. Various disorders in blood lipids and lipoproteins are identified. In this regard, there are certain recommendations for the analysis of lipids and lipoproteins in certain situations. The issues of interpreting extreme deviations from normal values of the blood lipid spectrum are discussed. Patient groups with different levels of the cardiovascular risk, which determines prescription of lipid-lowering therapy, are presented. Statins are the first line of lipid-lowering therapy for both the correction of dyslipidemia and the prevention of cardiovascular complications. The article discusses the tactics of prescribing statins in special groups of patients, their safety issues. It considers promising ways for increasing statins tolerability in patients with chronic liver diseases, primarily with non-alcoholic fatty liver disease, by adding of combined hepatoprotector. Conclusions.Generally, modern tactics of statins prescription are based on dyslipidemia characteristics and the patients cardiovascular risk level. Moreover, statins are clinically effective in special patient groups and have a good tolerability profile.Marina G. BubnovaLev E. ParnesConcilium Medicumarticledyslipidemiaatherosclerosisstatinschronic liver diseaseshepatoprotectorsDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENRUКардиоСоматика, Vol 11, Iss 1, Pp 6-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	dyslipidemia atherosclerosis statins chronic liver diseases hepatoprotectors Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	dyslipidemia atherosclerosis statins chronic liver diseases hepatoprotectors Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Marina G. Bubnova Lev E. Parnes Modern principles of atherogenic dyslipidemia management in special groups of patients
description	Aim.To provide modern view on atherogenic disorders in the blood lipid spectrum, the principles of lipid-lowering therapy prescription in certain groups of patients, the safety issues of statin therapy in patients with chronic liver diseases. Materials and methods.The data of 55 scientific sources published in the Russian and foreign press in 19882020 were analyzed. Results.It is known that atherogenic dyslipidemia is a key factor in pathogenesis of atherosclerotic cardiovascular diseases. Various disorders in blood lipids and lipoproteins are identified. In this regard, there are certain recommendations for the analysis of lipids and lipoproteins in certain situations. The issues of interpreting extreme deviations from normal values of the blood lipid spectrum are discussed. Patient groups with different levels of the cardiovascular risk, which determines prescription of lipid-lowering therapy, are presented. Statins are the first line of lipid-lowering therapy for both the correction of dyslipidemia and the prevention of cardiovascular complications. The article discusses the tactics of prescribing statins in special groups of patients, their safety issues. It considers promising ways for increasing statins tolerability in patients with chronic liver diseases, primarily with non-alcoholic fatty liver disease, by adding of combined hepatoprotector. Conclusions.Generally, modern tactics of statins prescription are based on dyslipidemia characteristics and the patients cardiovascular risk level. Moreover, statins are clinically effective in special patient groups and have a good tolerability profile.
format	article
author	Marina G. Bubnova Lev E. Parnes
author_facet	Marina G. Bubnova Lev E. Parnes
author_sort	Marina G. Bubnova
title	Modern principles of atherogenic dyslipidemia management in special groups of patients
title_short	Modern principles of atherogenic dyslipidemia management in special groups of patients
title_full	Modern principles of atherogenic dyslipidemia management in special groups of patients
title_fullStr	Modern principles of atherogenic dyslipidemia management in special groups of patients
title_full_unstemmed	Modern principles of atherogenic dyslipidemia management in special groups of patients
title_sort	modern principles of atherogenic dyslipidemia management in special groups of patients
publisher	Concilium Medicum
publishDate	2020
url	https://doaj.org/article/197447f5eafe4ae5877e61437824d9c4
work_keys_str_mv	AT marinagbubnova modernprinciplesofatherogenicdyslipidemiamanagementinspecialgroupsofpatients AT leveparnes modernprinciplesofatherogenicdyslipidemiamanagementinspecialgroupsofpatients
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Modern principles of atherogenic dyslipidemia management in special groups of patients

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