Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.

<h4>Background</h4>Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A...

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Autores principales:	Bachti Alisjahbana, Raspati Cundarani Koesoemadinata, Panji Fortuna Hadisoemarto, Bony Wiem Lestari, Sri Hartati, Lidya Chaidir, Chuan-Chin Huang, Megan Murray, Philip Campbell Hill, Susan Margaret McAllister
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1978afa851124e59a665aee89890887a
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spelling	oai:doaj.org-article:1978afa851124e59a665aee89890887a2021-12-02T20:18:09ZAre neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.1932-620310.1371/journal.pone.0256043https://doaj.org/article/1978afa851124e59a665aee89890887a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256043https://doaj.org/toc/1932-6203<h4>Background</h4>Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A better understanding of transmission dynamics in an urban setting in Indonesia will be crucial for the TB Control Program in scaling up efforts towards elimination of TB in a more targeted way. Therefore, the study aims to measure TB prevalence and incidence in household contacts and neighbourhoods in the vicinity of known TB cases and to assess their genomic and epidemiological relatedness.<h4>Methods and analysis</h4>Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. Whole-genome sequencing (WGS) and social network analysis (SNA) will be conducted on Index cases and contacts diagnosed with TB.Bachti AlisjahbanaRaspati Cundarani KoesoemadinataPanji Fortuna HadisoemartoBony Wiem LestariSri HartatiLidya ChaidirChuan-Chin HuangMegan MurrayPhilip Campbell HillSusan Margaret McAllisterPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0256043 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bachti Alisjahbana Raspati Cundarani Koesoemadinata Panji Fortuna Hadisoemarto Bony Wiem Lestari Sri Hartati Lidya Chaidir Chuan-Chin Huang Megan Murray Philip Campbell Hill Susan Margaret McAllister Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.
description	<h4>Background</h4>Indonesia has the second largest tuberculosis (TB) burden globally. Attempts to scale-up TB control efforts have focused on TB households. However, in most high burden settings, considerable Mycobacterium tuberculosis (Mtb) transmission occurs outside TB households. A better understanding of transmission dynamics in an urban setting in Indonesia will be crucial for the TB Control Program in scaling up efforts towards elimination of TB in a more targeted way. Therefore, the study aims to measure TB prevalence and incidence in household contacts and neighbourhoods in the vicinity of known TB cases and to assess their genomic and epidemiological relatedness.<h4>Methods and analysis</h4>Individuals (~1000) living in the same household as a case diagnosed with pulmonary TB (n = 250) or in a neighbouring household (~4500 individuals) will be screened for TB symptoms and by chest x-ray. Two sputum samples will be collected for microbiological analysis from anyone with a productive cough. Any person found to have TB will be treated by the National TB Control Program. All those with no evidence of TB disease will have a repeat screen at 12 months. Whole-genome sequencing (WGS) and social network analysis (SNA) will be conducted on Index cases and contacts diagnosed with TB.
format	article
author	Bachti Alisjahbana Raspati Cundarani Koesoemadinata Panji Fortuna Hadisoemarto Bony Wiem Lestari Sri Hartati Lidya Chaidir Chuan-Chin Huang Megan Murray Philip Campbell Hill Susan Margaret McAllister
author_facet	Bachti Alisjahbana Raspati Cundarani Koesoemadinata Panji Fortuna Hadisoemarto Bony Wiem Lestari Sri Hartati Lidya Chaidir Chuan-Chin Huang Megan Murray Philip Campbell Hill Susan Margaret McAllister
author_sort	Bachti Alisjahbana
title	Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.
title_short	Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.
title_full	Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.
title_fullStr	Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.
title_full_unstemmed	Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.
title_sort	are neighbourhoods of tuberculosis cases a high-risk population for active intervention? a protocol for tuberculosis active case finding.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1978afa851124e59a665aee89890887a
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Are neighbourhoods of tuberculosis cases a high-risk population for active intervention? A protocol for tuberculosis active case finding.

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