Possible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics

The human genome consists of roughly 23000 genes which cannot explain the enormous diversity of proteins or behavior. A second epigenetic code warrants adaptive variation of gene expression. The rationale of this variation are transfer reactions such as methylation, acetylation or phosphorylation of...

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Autor principal:	Koch H. J.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	epigenetics electroconvulsive therapy dna rna histone transferase enzyme family gene expression new hypothesis Medicine R
Acceso en línea:	https://doaj.org/article/197a62a48a3b41529ffe5564cd137ed3
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spelling	oai:doaj.org-article:197a62a48a3b41529ffe5564cd137ed32021-12-05T14:11:06ZPossible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics2719-538410.2478/amb-2021-0049https://doaj.org/article/197a62a48a3b41529ffe5564cd137ed32021-11-01T00:00:00Zhttps://doi.org/10.2478/amb-2021-0049https://doaj.org/toc/2719-5384The human genome consists of roughly 23000 genes which cannot explain the enormous diversity of proteins or behavior. A second epigenetic code warrants adaptive variation of gene expression. The rationale of this variation are transfer reactions such as methylation, acetylation or phosphorylation of DNA or histones including reverse reactions which are supposed to be altered by electroconvulsive therapy (ECT). The method has been successfully used since the 1930ies but the underlying molecular mechanism of action has not been elucidated yet. The paper discusses the theoretical involvement of epigenetic gene expression as an adaptive process to explain biochemical changes after ECT administration.Koch H. J.Sciendoarticleepigeneticselectroconvulsive therapydnarnahistonetransferase enzyme familygene expressionnew hypothesisMedicineRENActa Medica Bulgarica, Vol 48, Iss 4, Pp 57-61 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epigenetics electroconvulsive therapy dna rna histone transferase enzyme family gene expression new hypothesis Medicine R
spellingShingle	epigenetics electroconvulsive therapy dna rna histone transferase enzyme family gene expression new hypothesis Medicine R Koch H. J. Possible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics
description	The human genome consists of roughly 23000 genes which cannot explain the enormous diversity of proteins or behavior. A second epigenetic code warrants adaptive variation of gene expression. The rationale of this variation are transfer reactions such as methylation, acetylation or phosphorylation of DNA or histones including reverse reactions which are supposed to be altered by electroconvulsive therapy (ECT). The method has been successfully used since the 1930ies but the underlying molecular mechanism of action has not been elucidated yet. The paper discusses the theoretical involvement of epigenetic gene expression as an adaptive process to explain biochemical changes after ECT administration.
format	article
author	Koch H. J.
author_facet	Koch H. J.
author_sort	Koch H. J.
title	Possible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics
title_short	Possible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics
title_full	Possible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics
title_fullStr	Possible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics
title_full_unstemmed	Possible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics
title_sort	possible hypothetical mode of action of ect (electroconvulsive therapy) based on dna dipole character and epigenetics
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/197a62a48a3b41529ffe5564cd137ed3
work_keys_str_mv	AT kochhj possiblehypotheticalmodeofactionofectelectroconvulsivetherapybasedondnadipolecharacterandepigenetics
_version_	1718371404659818496

Possible Hypothetical Mode of Action of ECT (Electroconvulsive Therapy) Based on DNA Dipole Character and Epigenetics

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