Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system

Abstract Axo-glial units are highly organised microstructures propagating saltatory conduction and are disrupted during multiple sclerosis (MS). Nogo receptor 1 (NgR1) has been suggested to govern axonal damage during the progression of disease in the MS-like mouse model, experimental autoimmune enc...

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Autores principales:	Jae Young Lee, Min Joung Kim, Lijun Li, Alexander A. Velumian, Pei Mun Aui, Michael G. Fehlings, Steven Petratos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/197b50c75e844a8aa8e5034bba54e024
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spelling	oai:doaj.org-article:197b50c75e844a8aa8e5034bba54e0242021-12-02T11:52:44ZNogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system10.1038/s41598-017-09405-92045-2322https://doaj.org/article/197b50c75e844a8aa8e5034bba54e0242017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09405-9https://doaj.org/toc/2045-2322Abstract Axo-glial units are highly organised microstructures propagating saltatory conduction and are disrupted during multiple sclerosis (MS). Nogo receptor 1 (NgR1) has been suggested to govern axonal damage during the progression of disease in the MS-like mouse model, experimental autoimmune encephalomyelitis (EAE). Here we have identified that adult ngr1 −/− mice, previously used in EAE and spinal cord injury experiments, display elongated paranodes, and nodes of Ranvier. Unstructured paranodal regions in ngr1 −/− mice are matched with more distributed expression pattern of Caspr. Compound action potentials of optic nerves and spinal cords from naïve ngr1 −/− mice are delayed and reduced. Molecular interaction studies revealed enhanced Caspr cleavage. Our data suggest that NgR1 may regulate axo-myelin ultrastructure through Caspr-mediated adhesion, regulating the electrophysiological signature of myelinated axons of central nervous system (CNS).Jae Young LeeMin Joung KimLijun LiAlexander A. VelumianPei Mun AuiMichael G. FehlingsSteven PetratosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jae Young Lee Min Joung Kim Lijun Li Alexander A. Velumian Pei Mun Aui Michael G. Fehlings Steven Petratos Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system
description	Abstract Axo-glial units are highly organised microstructures propagating saltatory conduction and are disrupted during multiple sclerosis (MS). Nogo receptor 1 (NgR1) has been suggested to govern axonal damage during the progression of disease in the MS-like mouse model, experimental autoimmune encephalomyelitis (EAE). Here we have identified that adult ngr1 −/− mice, previously used in EAE and spinal cord injury experiments, display elongated paranodes, and nodes of Ranvier. Unstructured paranodal regions in ngr1 −/− mice are matched with more distributed expression pattern of Caspr. Compound action potentials of optic nerves and spinal cords from naïve ngr1 −/− mice are delayed and reduced. Molecular interaction studies revealed enhanced Caspr cleavage. Our data suggest that NgR1 may regulate axo-myelin ultrastructure through Caspr-mediated adhesion, regulating the electrophysiological signature of myelinated axons of central nervous system (CNS).
format	article
author	Jae Young Lee Min Joung Kim Lijun Li Alexander A. Velumian Pei Mun Aui Michael G. Fehlings Steven Petratos
author_facet	Jae Young Lee Min Joung Kim Lijun Li Alexander A. Velumian Pei Mun Aui Michael G. Fehlings Steven Petratos
author_sort	Jae Young Lee
title	Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system
title_short	Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system
title_full	Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system
title_fullStr	Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system
title_full_unstemmed	Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system
title_sort	nogo receptor 1 regulates caspr distribution at axo-glial units in the central nervous system
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/197b50c75e844a8aa8e5034bba54e024
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_version_	1718394909826744320

Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system

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