Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus

Abstract Periventricular white matter changes are common in patients with idiopathic normal pressure hydrocephalus (iNPH) and considered to represent focally elevated interstitial fluid. We compared diffusion measures in periventricular hyperintensities in patients with imaging features of iNPH to p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexander Rau, Marco Reisert, Elias Kellner, Jonas A. Hosp, Horst Urbach, Theo Demerath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/197e8c301fdb4214ab1f0ac303ef072c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:197e8c301fdb4214ab1f0ac303ef072c
record_format	dspace
spelling	oai:doaj.org-article:197e8c301fdb4214ab1f0ac303ef072c2021-12-02T18:51:07ZIncreased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus10.1038/s41598-021-98054-02045-2322https://doaj.org/article/197e8c301fdb4214ab1f0ac303ef072c2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98054-0https://doaj.org/toc/2045-2322Abstract Periventricular white matter changes are common in patients with idiopathic normal pressure hydrocephalus (iNPH) and considered to represent focally elevated interstitial fluid. We compared diffusion measures in periventricular hyperintensities in patients with imaging features of iNPH to patients without. The hypothesis is that periventricular hyperintensities in patients with presumed iNPH show higher water content than in patients without imaging features of iNPH. 21 patients with iNPH Radscale 7–12 (“high probability of iNPH”) and 10 patients with iNPH Radscale 2–4 (“low probability of iNPH”) were examined with a neurodegeneration imaging protocol including a diffusion microstructure imaging sequence. Periventricular hyperintensities and deep white matter hyperintensities were segmented and diffusion measures were compared. In patients with imaging features of iNPH, the free water content in periventricular hyperintensities was significantly higher compared to the control group (p = 0.005). This effect was also detectable in deep white matter hyperintensities (p = 0.024). Total brain volumes and total gray or white matter volumes did not differ between the groups. Periventricular cap free water fraction was highly discriminative regarding patients with presumed iNPH and controls with an ROC AUC of 0.933. Quantitative diffusion microstructure imaging shows elevated water content in periventricular hyperintensities in patients with imaging features of iNPH, which could be the imaging correlate for pathologic fluid accumulation and may be used as an imaging biomarker in the future.Alexander RauMarco ReisertElias KellnerJonas A. HospHorst UrbachTheo DemerathNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander Rau Marco Reisert Elias Kellner Jonas A. Hosp Horst Urbach Theo Demerath Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus
description	Abstract Periventricular white matter changes are common in patients with idiopathic normal pressure hydrocephalus (iNPH) and considered to represent focally elevated interstitial fluid. We compared diffusion measures in periventricular hyperintensities in patients with imaging features of iNPH to patients without. The hypothesis is that periventricular hyperintensities in patients with presumed iNPH show higher water content than in patients without imaging features of iNPH. 21 patients with iNPH Radscale 7–12 (“high probability of iNPH”) and 10 patients with iNPH Radscale 2–4 (“low probability of iNPH”) were examined with a neurodegeneration imaging protocol including a diffusion microstructure imaging sequence. Periventricular hyperintensities and deep white matter hyperintensities were segmented and diffusion measures were compared. In patients with imaging features of iNPH, the free water content in periventricular hyperintensities was significantly higher compared to the control group (p = 0.005). This effect was also detectable in deep white matter hyperintensities (p = 0.024). Total brain volumes and total gray or white matter volumes did not differ between the groups. Periventricular cap free water fraction was highly discriminative regarding patients with presumed iNPH and controls with an ROC AUC of 0.933. Quantitative diffusion microstructure imaging shows elevated water content in periventricular hyperintensities in patients with imaging features of iNPH, which could be the imaging correlate for pathologic fluid accumulation and may be used as an imaging biomarker in the future.
format	article
author	Alexander Rau Marco Reisert Elias Kellner Jonas A. Hosp Horst Urbach Theo Demerath
author_facet	Alexander Rau Marco Reisert Elias Kellner Jonas A. Hosp Horst Urbach Theo Demerath
author_sort	Alexander Rau
title	Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus
title_short	Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus
title_full	Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus
title_fullStr	Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus
title_full_unstemmed	Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus
title_sort	increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/197e8c301fdb4214ab1f0ac303ef072c
work_keys_str_mv	AT alexanderrau increasedinterstitialfluidinperiventricularanddeepwhitematterhyperintensitiesinpatientswithsuspectedidiopathicnormalpressurehydrocephalus AT marcoreisert increasedinterstitialfluidinperiventricularanddeepwhitematterhyperintensitiesinpatientswithsuspectedidiopathicnormalpressurehydrocephalus AT eliaskellner increasedinterstitialfluidinperiventricularanddeepwhitematterhyperintensitiesinpatientswithsuspectedidiopathicnormalpressurehydrocephalus AT jonasahosp increasedinterstitialfluidinperiventricularanddeepwhitematterhyperintensitiesinpatientswithsuspectedidiopathicnormalpressurehydrocephalus AT horsturbach increasedinterstitialfluidinperiventricularanddeepwhitematterhyperintensitiesinpatientswithsuspectedidiopathicnormalpressurehydrocephalus AT theodemerath increasedinterstitialfluidinperiventricularanddeepwhitematterhyperintensitiesinpatientswithsuspectedidiopathicnormalpressurehydrocephalus
_version_	1718377430954016768

Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus

Ejemplares similares