RyR1-related myopathy mutations in ATP and calcium binding sites impair channel regulation
Abstract The type 1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel on the sarcoplasmic/endoplasmic reticulum that is required for skeletal muscle contraction. RyR1 channel activity is modulated by ligands, including the activators Ca2+ and ATP. Patients with inherited m...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
BMC
2021
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| Accès en ligne: | https://doaj.org/article/19800ceb1bb3470a8e10bc36391ea39b |
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