Improved measures for evolutionary conservation that exploit taxonomy distances

Information on protein sequence variability and conservation can be leveraged to identify functionally important regions. Here, the authors develop new conservation measures that exploit taxonomy distances and LIST, a tool for predicting deleteriousness of human variants.

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Detalles Bibliográficos
Autores principales:	Nawar Malhis, Steven J. M. Jones, Jörg Gsponer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/19806ffe4cf2405a9013b781a10363c3
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spelling	oai:doaj.org-article:19806ffe4cf2405a9013b781a10363c32021-12-02T14:40:02ZImproved measures for evolutionary conservation that exploit taxonomy distances10.1038/s41467-019-09583-22041-1723https://doaj.org/article/19806ffe4cf2405a9013b781a10363c32019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09583-2https://doaj.org/toc/2041-1723Information on protein sequence variability and conservation can be leveraged to identify functionally important regions. Here, the authors develop new conservation measures that exploit taxonomy distances and LIST, a tool for predicting deleteriousness of human variants.Nawar MalhisSteven J. M. JonesJörg GsponerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nawar Malhis Steven J. M. Jones Jörg Gsponer Improved measures for evolutionary conservation that exploit taxonomy distances
description	Information on protein sequence variability and conservation can be leveraged to identify functionally important regions. Here, the authors develop new conservation measures that exploit taxonomy distances and LIST, a tool for predicting deleteriousness of human variants.
format	article
author	Nawar Malhis Steven J. M. Jones Jörg Gsponer
author_facet	Nawar Malhis Steven J. M. Jones Jörg Gsponer
author_sort	Nawar Malhis
title	Improved measures for evolutionary conservation that exploit taxonomy distances
title_short	Improved measures for evolutionary conservation that exploit taxonomy distances
title_full	Improved measures for evolutionary conservation that exploit taxonomy distances
title_fullStr	Improved measures for evolutionary conservation that exploit taxonomy distances
title_full_unstemmed	Improved measures for evolutionary conservation that exploit taxonomy distances
title_sort	improved measures for evolutionary conservation that exploit taxonomy distances
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/19806ffe4cf2405a9013b781a10363c3
work_keys_str_mv	AT nawarmalhis improvedmeasuresforevolutionaryconservationthatexploittaxonomydistances AT stevenjmjones improvedmeasuresforevolutionaryconservationthatexploittaxonomydistances AT jorggsponer improvedmeasuresforevolutionaryconservationthatexploittaxonomydistances
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Improved measures for evolutionary conservation that exploit taxonomy distances

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