Improved measures for evolutionary conservation that exploit taxonomy distances

Information on protein sequence variability and conservation can be leveraged to identify functionally important regions. Here, the authors develop new conservation measures that exploit taxonomy distances and LIST, a tool for predicting deleteriousness of human variants.

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Bibliographic Details
Main Authors: Nawar Malhis, Steven J. M. Jones, Jörg Gsponer
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Q
Online Access:https://doaj.org/article/19806ffe4cf2405a9013b781a10363c3
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