The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.

The budding yeast Saccharomyces cerevisiae has developed several mechanisms to avoid either the drastic consequences of iron deprivation or the toxic effects of iron excess. In this work, we analysed the global gene expression changes occurring in yeast cells undergoing iron overload. Several genes...

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Autores principales:	Catarina Pimentel, Cristina Vicente, Regina Andrade Menezes, Soraia Caetano, Laura Carreto, Claudina Rodrigues-Pousada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/198447b4b45743a1b321c17e44e665a3
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spelling	oai:doaj.org-article:198447b4b45743a1b321c17e44e665a32021-11-18T07:18:26ZThe role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.1932-620310.1371/journal.pone.0037434https://doaj.org/article/198447b4b45743a1b321c17e44e665a32012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22616008/?tool=EBIhttps://doaj.org/toc/1932-6203The budding yeast Saccharomyces cerevisiae has developed several mechanisms to avoid either the drastic consequences of iron deprivation or the toxic effects of iron excess. In this work, we analysed the global gene expression changes occurring in yeast cells undergoing iron overload. Several genes directly or indirectly involved in iron homeostasis showed altered expression and the relevance of these changes are discussed. Microarray analyses were also performed to identify new targets of the iron responsive factor Yap5. Besides the iron vacuolar transporter CCC1, Yap5 also controls the expression of glutaredoxin GRX4, previously known to be involved in the regulation of Aft1 nuclear localization. Consistently, we show that in the absence of Yap5 Aft1 nuclear exclusion is slightly impaired. These studies provide further evidence that cells control iron homeostasis by using multiple pathways.Catarina PimentelCristina VicenteRegina Andrade MenezesSoraia CaetanoLaura CarretoClaudina Rodrigues-PousadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e37434 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Catarina Pimentel Cristina Vicente Regina Andrade Menezes Soraia Caetano Laura Carreto Claudina Rodrigues-Pousada The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.
description	The budding yeast Saccharomyces cerevisiae has developed several mechanisms to avoid either the drastic consequences of iron deprivation or the toxic effects of iron excess. In this work, we analysed the global gene expression changes occurring in yeast cells undergoing iron overload. Several genes directly or indirectly involved in iron homeostasis showed altered expression and the relevance of these changes are discussed. Microarray analyses were also performed to identify new targets of the iron responsive factor Yap5. Besides the iron vacuolar transporter CCC1, Yap5 also controls the expression of glutaredoxin GRX4, previously known to be involved in the regulation of Aft1 nuclear localization. Consistently, we show that in the absence of Yap5 Aft1 nuclear exclusion is slightly impaired. These studies provide further evidence that cells control iron homeostasis by using multiple pathways.
format	article
author	Catarina Pimentel Cristina Vicente Regina Andrade Menezes Soraia Caetano Laura Carreto Claudina Rodrigues-Pousada
author_facet	Catarina Pimentel Cristina Vicente Regina Andrade Menezes Soraia Caetano Laura Carreto Claudina Rodrigues-Pousada
author_sort	Catarina Pimentel
title	The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.
title_short	The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.
title_full	The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.
title_fullStr	The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.
title_full_unstemmed	The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.
title_sort	role of the yap5 transcription factor in remodeling gene expression in response to fe bioavailability.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/198447b4b45743a1b321c17e44e665a3
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The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability.

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