Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

Directed protein degradation to target hard-to-drug proteins is a promising therapeutic approach. Here, the authors report the prospective discovery of small molecule “molecular glue” that inserts into a naturally occurring E3 ligase-substrate interface leading to degradation of substrate protein....

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Autores principales:	Kyle R. Simonetta, Joshua Taygerly, Kathleen Boyle, Stephen E. Basham, Chris Padovani, Yan Lou, Thomas J. Cummins, Stephanie L. Yung, Szerenke Kiss von Soly, Frank Kayser, John Kuriyan, Michael Rape, Mario Cardozo, Mark A. Gallop, Neil F. Bence, Paul A. Barsanti, Anjanabha Saha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee3135
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spelling	oai:doaj.org-article:1987a6eabdf140cbaf14746bd1ee31352021-12-02T15:35:56ZProspective discovery of small molecule enhancers of an E3 ligase-substrate interaction10.1038/s41467-019-09358-92041-1723https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee31352019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09358-9https://doaj.org/toc/2041-1723Directed protein degradation to target hard-to-drug proteins is a promising therapeutic approach. Here, the authors report the prospective discovery of small molecule “molecular glue” that inserts into a naturally occurring E3 ligase-substrate interface leading to degradation of substrate protein.Kyle R. SimonettaJoshua TaygerlyKathleen BoyleStephen E. BashamChris PadovaniYan LouThomas J. CumminsStephanie L. YungSzerenke Kiss von SolyFrank KayserJohn KuriyanMichael RapeMario CardozoMark A. GallopNeil F. BencePaul A. BarsantiAnjanabha SahaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyle R. Simonetta Joshua Taygerly Kathleen Boyle Stephen E. Basham Chris Padovani Yan Lou Thomas J. Cummins Stephanie L. Yung Szerenke Kiss von Soly Frank Kayser John Kuriyan Michael Rape Mario Cardozo Mark A. Gallop Neil F. Bence Paul A. Barsanti Anjanabha Saha Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
description	Directed protein degradation to target hard-to-drug proteins is a promising therapeutic approach. Here, the authors report the prospective discovery of small molecule “molecular glue” that inserts into a naturally occurring E3 ligase-substrate interface leading to degradation of substrate protein.
format	article
author	Kyle R. Simonetta Joshua Taygerly Kathleen Boyle Stephen E. Basham Chris Padovani Yan Lou Thomas J. Cummins Stephanie L. Yung Szerenke Kiss von Soly Frank Kayser John Kuriyan Michael Rape Mario Cardozo Mark A. Gallop Neil F. Bence Paul A. Barsanti Anjanabha Saha
author_facet	Kyle R. Simonetta Joshua Taygerly Kathleen Boyle Stephen E. Basham Chris Padovani Yan Lou Thomas J. Cummins Stephanie L. Yung Szerenke Kiss von Soly Frank Kayser John Kuriyan Michael Rape Mario Cardozo Mark A. Gallop Neil F. Bence Paul A. Barsanti Anjanabha Saha
author_sort	Kyle R. Simonetta
title	Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
title_short	Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
title_full	Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
title_fullStr	Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
title_full_unstemmed	Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
title_sort	prospective discovery of small molecule enhancers of an e3 ligase-substrate interaction
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee3135
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Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

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