An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis
Our understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify nine CpGs not previously implicated in glucose, ins...
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| Lenguaje: | EN |
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Nature Portfolio
2019
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| Acceso en línea: | https://doaj.org/article/19891659495247948d3d723f24545ddd |
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oai:doaj.org-article:19891659495247948d3d723f24545ddd2021-12-02T14:40:21ZAn integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis10.1038/s41467-019-10487-42041-1723https://doaj.org/article/19891659495247948d3d723f24545ddd2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10487-4https://doaj.org/toc/2041-1723Our understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify nine CpGs not previously implicated in glucose, insulin homeostasis and diabetes.Jun LiuElena Carnero-MontoroJenny van DongenSamantha LentIvana NedeljkovicSymen LigthartPei-Chien TsaiTiphaine C. MartinPooja R. MandaviyaRick JansenMarjolein J. PetersLiesbeth DuijtsVincent W. V. JaddoeHenning TiemeierJanine F. FelixGonneke WillemsenEco J. C. de GeusAudrey Y. ChuDaniel LevyShih-Jen HwangJan BresslerRahul GondaliaElias L. SalfatiChristian HerderBertha A. HidalgoToshiko TanakaAnn Zenobia MooreRozenn N. LemaitreMin A JhunJennifer A. SmithNona SotoodehniaStefania BandinelliLuigi FerrucciDonna K. ArnettHarald GrallertThemistocles L. AssimesLifang HouAndrea BaccarelliEric A. WhitselKo Willems van DijkNajaf AminAndré G. UitterlindenEric J. G. SijbrandsOscar H. FrancoAbbas DehghanTim D. SpectorJosée DupuisMarie-France HivertJerome I. RotterJames B. MeigsJames S. PankowJoyce B. J. van MeursAaron IsaacsDorret I. BoomsmaJordana T. BellAyşe DemirkanCornelia M. van DuijnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jun Liu Elena Carnero-Montoro Jenny van Dongen Samantha Lent Ivana Nedeljkovic Symen Ligthart Pei-Chien Tsai Tiphaine C. Martin Pooja R. Mandaviya Rick Jansen Marjolein J. Peters Liesbeth Duijts Vincent W. V. Jaddoe Henning Tiemeier Janine F. Felix Gonneke Willemsen Eco J. C. de Geus Audrey Y. Chu Daniel Levy Shih-Jen Hwang Jan Bressler Rahul Gondalia Elias L. Salfati Christian Herder Bertha A. Hidalgo Toshiko Tanaka Ann Zenobia Moore Rozenn N. Lemaitre Min A Jhun Jennifer A. Smith Nona Sotoodehnia Stefania Bandinelli Luigi Ferrucci Donna K. Arnett Harald Grallert Themistocles L. Assimes Lifang Hou Andrea Baccarelli Eric A. Whitsel Ko Willems van Dijk Najaf Amin André G. Uitterlinden Eric J. G. Sijbrands Oscar H. Franco Abbas Dehghan Tim D. Spector Josée Dupuis Marie-France Hivert Jerome I. Rotter James B. Meigs James S. Pankow Joyce B. J. van Meurs Aaron Isaacs Dorret I. Boomsma Jordana T. Bell Ayşe Demirkan Cornelia M. van Duijn An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| description |
Our understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify nine CpGs not previously implicated in glucose, insulin homeostasis and diabetes. |
| format |
article |
| author |
Jun Liu Elena Carnero-Montoro Jenny van Dongen Samantha Lent Ivana Nedeljkovic Symen Ligthart Pei-Chien Tsai Tiphaine C. Martin Pooja R. Mandaviya Rick Jansen Marjolein J. Peters Liesbeth Duijts Vincent W. V. Jaddoe Henning Tiemeier Janine F. Felix Gonneke Willemsen Eco J. C. de Geus Audrey Y. Chu Daniel Levy Shih-Jen Hwang Jan Bressler Rahul Gondalia Elias L. Salfati Christian Herder Bertha A. Hidalgo Toshiko Tanaka Ann Zenobia Moore Rozenn N. Lemaitre Min A Jhun Jennifer A. Smith Nona Sotoodehnia Stefania Bandinelli Luigi Ferrucci Donna K. Arnett Harald Grallert Themistocles L. Assimes Lifang Hou Andrea Baccarelli Eric A. Whitsel Ko Willems van Dijk Najaf Amin André G. Uitterlinden Eric J. G. Sijbrands Oscar H. Franco Abbas Dehghan Tim D. Spector Josée Dupuis Marie-France Hivert Jerome I. Rotter James B. Meigs James S. Pankow Joyce B. J. van Meurs Aaron Isaacs Dorret I. Boomsma Jordana T. Bell Ayşe Demirkan Cornelia M. van Duijn |
| author_facet |
Jun Liu Elena Carnero-Montoro Jenny van Dongen Samantha Lent Ivana Nedeljkovic Symen Ligthart Pei-Chien Tsai Tiphaine C. Martin Pooja R. Mandaviya Rick Jansen Marjolein J. Peters Liesbeth Duijts Vincent W. V. Jaddoe Henning Tiemeier Janine F. Felix Gonneke Willemsen Eco J. C. de Geus Audrey Y. Chu Daniel Levy Shih-Jen Hwang Jan Bressler Rahul Gondalia Elias L. Salfati Christian Herder Bertha A. Hidalgo Toshiko Tanaka Ann Zenobia Moore Rozenn N. Lemaitre Min A Jhun Jennifer A. Smith Nona Sotoodehnia Stefania Bandinelli Luigi Ferrucci Donna K. Arnett Harald Grallert Themistocles L. Assimes Lifang Hou Andrea Baccarelli Eric A. Whitsel Ko Willems van Dijk Najaf Amin André G. Uitterlinden Eric J. G. Sijbrands Oscar H. Franco Abbas Dehghan Tim D. Spector Josée Dupuis Marie-France Hivert Jerome I. Rotter James B. Meigs James S. Pankow Joyce B. J. van Meurs Aaron Isaacs Dorret I. Boomsma Jordana T. Bell Ayşe Demirkan Cornelia M. van Duijn |
| author_sort |
Jun Liu |
| title |
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| title_short |
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| title_full |
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| title_fullStr |
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| title_full_unstemmed |
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
| title_sort |
integrative cross-omics analysis of dna methylation sites of glucose and insulin homeostasis |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/19891659495247948d3d723f24545ddd |
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