Low-level alcohol consumption and cancer mortality

Abstract The effect of light-to-moderate alcohol consumption on cancer risk remains controversial. We examined the association between low-level alcohol consumption and cancer mortality. A cohort study included 331,984 Korean adults free of cancer at baseline who underwent a comprehensive health che...

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Autores principales:	Hyeonyoung Ko, Yoosoo Chang, Han-Na Kim, Jae-Heon Kang, Hocheol Shin, Eunju Sung, Seungho Ryu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/198bcf58fdf14535b6411d2a9006bc52
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spelling	oai:doaj.org-article:198bcf58fdf14535b6411d2a9006bc522021-12-02T11:35:52ZLow-level alcohol consumption and cancer mortality10.1038/s41598-021-84181-12045-2322https://doaj.org/article/198bcf58fdf14535b6411d2a9006bc522021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84181-1https://doaj.org/toc/2045-2322Abstract The effect of light-to-moderate alcohol consumption on cancer risk remains controversial. We examined the association between low-level alcohol consumption and cancer mortality. A cohort study included 331,984 Korean adults free of cancer at baseline who underwent a comprehensive health checkup examination. Participants were categorized into never drinkers, former drinkers, and current drinkers who were further divided into light, moderate, heavy, and very heavy drinkers. Vital status and cancer-related deaths were ascertained through links to national death records. During 1,633,906 person-years of follow-up (median 5.3 years interquartile range 3.8–6.2), 374 cancer-related deaths were identified (cancer-cause mortality rate of 23 per 105 person-years). When former and never drinkers were classified as non-drinkers, the light drinkers had a lowest risk of cancer mortality compared with non-drinkers and other current drinkers (J-shaped); however, with consideration of lifetime abstinence history, current drinking was positively associated with cancer mortality in a dose-dependent manner. When changes in alcohol drinking status and confounders during follow-up were updated as time-varying covariates and never drinkers were used as the reference, the multivariable-adjusted hazard ratios (HRs) (95% confidence intervals, CIs) for cancer mortality among current light, moderate, heavy, and very heavy drinkers were 1.58 (1.03–2.43), 2.28 (1.41–3.70), 2.34 (1.42–3.85), and 2.97 (1.80–4.90), respectively, and the highest risk of cancer mortality was observed in former drinkers, who had an HR (95% CI) of 3.86 (2.38–6.28). Alcohol consumption was significantly and positively associated with an increased risk of cancer mortality in a dose-dependent manner, beginning with light drinkers.Hyeonyoung KoYoosoo ChangHan-Na KimJae-Heon KangHocheol ShinEunju SungSeungho RyuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyeonyoung Ko Yoosoo Chang Han-Na Kim Jae-Heon Kang Hocheol Shin Eunju Sung Seungho Ryu Low-level alcohol consumption and cancer mortality
description	Abstract The effect of light-to-moderate alcohol consumption on cancer risk remains controversial. We examined the association between low-level alcohol consumption and cancer mortality. A cohort study included 331,984 Korean adults free of cancer at baseline who underwent a comprehensive health checkup examination. Participants were categorized into never drinkers, former drinkers, and current drinkers who were further divided into light, moderate, heavy, and very heavy drinkers. Vital status and cancer-related deaths were ascertained through links to national death records. During 1,633,906 person-years of follow-up (median 5.3 years interquartile range 3.8–6.2), 374 cancer-related deaths were identified (cancer-cause mortality rate of 23 per 105 person-years). When former and never drinkers were classified as non-drinkers, the light drinkers had a lowest risk of cancer mortality compared with non-drinkers and other current drinkers (J-shaped); however, with consideration of lifetime abstinence history, current drinking was positively associated with cancer mortality in a dose-dependent manner. When changes in alcohol drinking status and confounders during follow-up were updated as time-varying covariates and never drinkers were used as the reference, the multivariable-adjusted hazard ratios (HRs) (95% confidence intervals, CIs) for cancer mortality among current light, moderate, heavy, and very heavy drinkers were 1.58 (1.03–2.43), 2.28 (1.41–3.70), 2.34 (1.42–3.85), and 2.97 (1.80–4.90), respectively, and the highest risk of cancer mortality was observed in former drinkers, who had an HR (95% CI) of 3.86 (2.38–6.28). Alcohol consumption was significantly and positively associated with an increased risk of cancer mortality in a dose-dependent manner, beginning with light drinkers.
format	article
author	Hyeonyoung Ko Yoosoo Chang Han-Na Kim Jae-Heon Kang Hocheol Shin Eunju Sung Seungho Ryu
author_facet	Hyeonyoung Ko Yoosoo Chang Han-Na Kim Jae-Heon Kang Hocheol Shin Eunju Sung Seungho Ryu
author_sort	Hyeonyoung Ko
title	Low-level alcohol consumption and cancer mortality
title_short	Low-level alcohol consumption and cancer mortality
title_full	Low-level alcohol consumption and cancer mortality
title_fullStr	Low-level alcohol consumption and cancer mortality
title_full_unstemmed	Low-level alcohol consumption and cancer mortality
title_sort	low-level alcohol consumption and cancer mortality
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/198bcf58fdf14535b6411d2a9006bc52
work_keys_str_mv	AT hyeonyoungko lowlevelalcoholconsumptionandcancermortality AT yoosoochang lowlevelalcoholconsumptionandcancermortality AT hannakim lowlevelalcoholconsumptionandcancermortality AT jaeheonkang lowlevelalcoholconsumptionandcancermortality AT hocheolshin lowlevelalcoholconsumptionandcancermortality AT eunjusung lowlevelalcoholconsumptionandcancermortality AT seunghoryu lowlevelalcoholconsumptionandcancermortality
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Low-level alcohol consumption and cancer mortality

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