Renal clearable nanochelators for iron overload therapy

The build-up of iron in the body can have serious consequences; current treatment therapies suffer from adverse side effects and toxicity. Here, the authors developed renal clearable nanochelators with improved pharmacodynamics and demonstrated their efficacy and safety in iron overload animal model...

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Autores principales: Homan Kang, Murui Han, Jie Xue, Yoonji Baek, JuOae Chang, Shuang Hu, HaYoung Nam, Min Joo Jo, Georges El Fakhri, Michael P. Hutchens, Hak Soo Choi, Jonghan Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/198c198f6b274783a6180df66ea4bffb
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Sumario:The build-up of iron in the body can have serious consequences; current treatment therapies suffer from adverse side effects and toxicity. Here, the authors developed renal clearable nanochelators with improved pharmacodynamics and demonstrated their efficacy and safety in iron overload animal models.