Renal clearable nanochelators for iron overload therapy

The build-up of iron in the body can have serious consequences; current treatment therapies suffer from adverse side effects and toxicity. Here, the authors developed renal clearable nanochelators with improved pharmacodynamics and demonstrated their efficacy and safety in iron overload animal model...

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Autores principales:	Homan Kang, Murui Han, Jie Xue, Yoonji Baek, JuOae Chang, Shuang Hu, HaYoung Nam, Min Joo Jo, Georges El Fakhri, Michael P. Hutchens, Hak Soo Choi, Jonghan Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/198c198f6b274783a6180df66ea4bffb
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spelling	oai:doaj.org-article:198c198f6b274783a6180df66ea4bffb2021-12-02T17:01:44ZRenal clearable nanochelators for iron overload therapy10.1038/s41467-019-13143-z2041-1723https://doaj.org/article/198c198f6b274783a6180df66ea4bffb2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13143-zhttps://doaj.org/toc/2041-1723The build-up of iron in the body can have serious consequences; current treatment therapies suffer from adverse side effects and toxicity. Here, the authors developed renal clearable nanochelators with improved pharmacodynamics and demonstrated their efficacy and safety in iron overload animal models.Homan KangMurui HanJie XueYoonji BaekJuOae ChangShuang HuHaYoung NamMin Joo JoGeorges El FakhriMichael P. HutchensHak Soo ChoiJonghan KimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Homan Kang Murui Han Jie Xue Yoonji Baek JuOae Chang Shuang Hu HaYoung Nam Min Joo Jo Georges El Fakhri Michael P. Hutchens Hak Soo Choi Jonghan Kim Renal clearable nanochelators for iron overload therapy
description	The build-up of iron in the body can have serious consequences; current treatment therapies suffer from adverse side effects and toxicity. Here, the authors developed renal clearable nanochelators with improved pharmacodynamics and demonstrated their efficacy and safety in iron overload animal models.
format	article
author	Homan Kang Murui Han Jie Xue Yoonji Baek JuOae Chang Shuang Hu HaYoung Nam Min Joo Jo Georges El Fakhri Michael P. Hutchens Hak Soo Choi Jonghan Kim
author_facet	Homan Kang Murui Han Jie Xue Yoonji Baek JuOae Chang Shuang Hu HaYoung Nam Min Joo Jo Georges El Fakhri Michael P. Hutchens Hak Soo Choi Jonghan Kim
author_sort	Homan Kang
title	Renal clearable nanochelators for iron overload therapy
title_short	Renal clearable nanochelators for iron overload therapy
title_full	Renal clearable nanochelators for iron overload therapy
title_fullStr	Renal clearable nanochelators for iron overload therapy
title_full_unstemmed	Renal clearable nanochelators for iron overload therapy
title_sort	renal clearable nanochelators for iron overload therapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/198c198f6b274783a6180df66ea4bffb
work_keys_str_mv	AT homankang renalclearablenanochelatorsforironoverloadtherapy AT muruihan renalclearablenanochelatorsforironoverloadtherapy AT jiexue renalclearablenanochelatorsforironoverloadtherapy AT yoonjibaek renalclearablenanochelatorsforironoverloadtherapy AT juoaechang renalclearablenanochelatorsforironoverloadtherapy AT shuanghu renalclearablenanochelatorsforironoverloadtherapy AT hayoungnam renalclearablenanochelatorsforironoverloadtherapy AT minjoojo renalclearablenanochelatorsforironoverloadtherapy AT georgeselfakhri renalclearablenanochelatorsforironoverloadtherapy AT michaelphutchens renalclearablenanochelatorsforironoverloadtherapy AT haksoochoi renalclearablenanochelatorsforironoverloadtherapy AT jonghankim renalclearablenanochelatorsforironoverloadtherapy
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Renal clearable nanochelators for iron overload therapy

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