Host Physiologic Changes Induced by Influenza A Virus Lead to <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease

ABSTRACT Staphylococcus aureus is a ubiquitous opportunistic human pathogen and a major health concern worldwide, causing a wide variety of diseases from mild skin infections to systemic disease. S. aureus is a major source of severe secondary bacterial pneumonia after influenza A virus infection, w...

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Autores principales:	Ryan M. Reddinger, Nicole R. Luke-Marshall, Anders P. Hakansson, Anthony A. Campagnari
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/198d8db4c08246b882620288626afa3a
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spelling	oai:doaj.org-article:198d8db4c08246b882620288626afa3a2021-11-15T15:50:18ZHost Physiologic Changes Induced by Influenza A Virus Lead to <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease10.1128/mBio.01235-162150-7511https://doaj.org/article/198d8db4c08246b882620288626afa3a2016-09-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01235-16https://doaj.org/toc/2150-7511ABSTRACT Staphylococcus aureus is a ubiquitous opportunistic human pathogen and a major health concern worldwide, causing a wide variety of diseases from mild skin infections to systemic disease. S. aureus is a major source of severe secondary bacterial pneumonia after influenza A virus infection, which causes widespread morbidity and mortality. While the phenomenon of secondary bacterial pneumonia is well established, the mechanisms behind the transition from asymptomatic colonization to invasive staphylococcal disease following viral infection remains unknown. In this report, we have shown that S. aureus biofilms, grown on an upper respiratory epithelial substratum, disperse in response to host physiologic changes related to viral infection, such as febrile range temperatures, exogenous ATP, norepinephrine, and increased glucose. Mice that were colonized with S. aureus and subsequently exposed to these physiologic stimuli or influenza A virus coinfection developed pronounced pneumonia. This study provides novel insight into the transition from colonization to invasive disease, providing a better understanding of the events involved in the pathogenesis of secondary staphylococcal pneumonia. IMPORTANCE In this study, we have determined that host physiologic changes related to influenza A virus infection causes S. aureus to disperse from a biofilm state. Additionally, we report that these same host physiologic changes promote S. aureus dissemination from the nasal tissue to the lungs in an animal model. Furthermore, this study identifies important aspects involved in the transition of S. aureus from asymptomatic colonization to pneumonia.Ryan M. ReddingerNicole R. Luke-MarshallAnders P. HakanssonAnthony A. CampagnariAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 4 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Ryan M. Reddinger Nicole R. Luke-Marshall Anders P. Hakansson Anthony A. Campagnari Host Physiologic Changes Induced by Influenza A Virus Lead to <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease
description	ABSTRACT Staphylococcus aureus is a ubiquitous opportunistic human pathogen and a major health concern worldwide, causing a wide variety of diseases from mild skin infections to systemic disease. S. aureus is a major source of severe secondary bacterial pneumonia after influenza A virus infection, which causes widespread morbidity and mortality. While the phenomenon of secondary bacterial pneumonia is well established, the mechanisms behind the transition from asymptomatic colonization to invasive staphylococcal disease following viral infection remains unknown. In this report, we have shown that S. aureus biofilms, grown on an upper respiratory epithelial substratum, disperse in response to host physiologic changes related to viral infection, such as febrile range temperatures, exogenous ATP, norepinephrine, and increased glucose. Mice that were colonized with S. aureus and subsequently exposed to these physiologic stimuli or influenza A virus coinfection developed pronounced pneumonia. This study provides novel insight into the transition from colonization to invasive disease, providing a better understanding of the events involved in the pathogenesis of secondary staphylococcal pneumonia. IMPORTANCE In this study, we have determined that host physiologic changes related to influenza A virus infection causes S. aureus to disperse from a biofilm state. Additionally, we report that these same host physiologic changes promote S. aureus dissemination from the nasal tissue to the lungs in an animal model. Furthermore, this study identifies important aspects involved in the transition of S. aureus from asymptomatic colonization to pneumonia.
format	article
author	Ryan M. Reddinger Nicole R. Luke-Marshall Anders P. Hakansson Anthony A. Campagnari
author_facet	Ryan M. Reddinger Nicole R. Luke-Marshall Anders P. Hakansson Anthony A. Campagnari
author_sort	Ryan M. Reddinger
title	Host Physiologic Changes Induced by Influenza A Virus Lead to <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease
title_short	Host Physiologic Changes Induced by Influenza A Virus Lead to <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease
title_full	Host Physiologic Changes Induced by Influenza A Virus Lead to <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease
title_fullStr	Host Physiologic Changes Induced by Influenza A Virus Lead to <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease
title_full_unstemmed	Host Physiologic Changes Induced by Influenza A Virus Lead to <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease
title_sort	host physiologic changes induced by influenza a virus lead to <named-content content-type="genus-species">staphylococcus aureus</named-content> biofilm dispersion and transition from asymptomatic colonization to invasive disease
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/198d8db4c08246b882620288626afa3a
work_keys_str_mv	AT ryanmreddinger hostphysiologicchangesinducedbyinfluenzaavirusleadtonamedcontentcontenttypegenusspeciesstaphylococcusaureusnamedcontentbiofilmdispersionandtransitionfromasymptomaticcolonizationtoinvasivedisease AT nicolerlukemarshall hostphysiologicchangesinducedbyinfluenzaavirusleadtonamedcontentcontenttypegenusspeciesstaphylococcusaureusnamedcontentbiofilmdispersionandtransitionfromasymptomaticcolonizationtoinvasivedisease AT andersphakansson hostphysiologicchangesinducedbyinfluenzaavirusleadtonamedcontentcontenttypegenusspeciesstaphylococcusaureusnamedcontentbiofilmdispersionandtransitionfromasymptomaticcolonizationtoinvasivedisease AT anthonyacampagnari hostphysiologicchangesinducedbyinfluenzaavirusleadtonamedcontentcontenttypegenusspeciesstaphylococcusaureusnamedcontentbiofilmdispersionandtransitionfromasymptomaticcolonizationtoinvasivedisease
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Host Physiologic Changes Induced by Influenza A Virus Lead to <named-content content-type="genus-species">Staphylococcus aureus</named-content> Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease

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