Approach and withdrawal motivation in schizophrenia: an examination of frontal brain asymmetric activity.

Although motivational disturbances are common in schizophrenia, their neurophysiological and psychological basis is poorly understood. This electroencephalography (EEG) study examined the well-established motivational direction model of asymmetric frontal brain activity in schizophrenia. According t...

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Autores principales:	William P Horan, Jonathan K Wynn, Ian Mathis, Gregory A Miller, Michael F Green
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/198e19989a954148bcc943885b287812
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spelling	oai:doaj.org-article:198e19989a954148bcc943885b2878122021-11-25T05:56:54ZApproach and withdrawal motivation in schizophrenia: an examination of frontal brain asymmetric activity.1932-620310.1371/journal.pone.0110007https://doaj.org/article/198e19989a954148bcc943885b2878122014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110007https://doaj.org/toc/1932-6203Although motivational disturbances are common in schizophrenia, their neurophysiological and psychological basis is poorly understood. This electroencephalography (EEG) study examined the well-established motivational direction model of asymmetric frontal brain activity in schizophrenia. According to this model, relative left frontal activity in the resting EEG reflects enhanced approach motivation tendencies, whereas relative right frontal activity reflects enhanced withdrawal motivation tendencies. Twenty-five schizophrenia outpatients and 25 healthy controls completed resting EEG assessments of frontal asymmetry in the alpha frequency band (8-12 Hz), as well as a self-report measure of behavioral activation and inhibition system (BIS/BAS) sensitivity. Patients showed an atypical pattern of differences from controls. On the EEG measure patients failed to show the left lateralized activity that was present in controls, suggesting diminished approach motivation. On the self-report measure, patients reported higher BIS sensitivity than controls, which is typically interpreted as heightened withdrawal motivation. EEG asymmetry scores did not significantly correlate with BIS/BAS scores or with clinical symptom ratings among patients. The overall pattern suggests a motivational disturbance in schizophrenia characterized by elements of both diminished approach and elevated withdrawal tendencies.William P HoranJonathan K WynnIan MathisGregory A MillerMichael F GreenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e110007 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q William P Horan Jonathan K Wynn Ian Mathis Gregory A Miller Michael F Green Approach and withdrawal motivation in schizophrenia: an examination of frontal brain asymmetric activity.
description	Although motivational disturbances are common in schizophrenia, their neurophysiological and psychological basis is poorly understood. This electroencephalography (EEG) study examined the well-established motivational direction model of asymmetric frontal brain activity in schizophrenia. According to this model, relative left frontal activity in the resting EEG reflects enhanced approach motivation tendencies, whereas relative right frontal activity reflects enhanced withdrawal motivation tendencies. Twenty-five schizophrenia outpatients and 25 healthy controls completed resting EEG assessments of frontal asymmetry in the alpha frequency band (8-12 Hz), as well as a self-report measure of behavioral activation and inhibition system (BIS/BAS) sensitivity. Patients showed an atypical pattern of differences from controls. On the EEG measure patients failed to show the left lateralized activity that was present in controls, suggesting diminished approach motivation. On the self-report measure, patients reported higher BIS sensitivity than controls, which is typically interpreted as heightened withdrawal motivation. EEG asymmetry scores did not significantly correlate with BIS/BAS scores or with clinical symptom ratings among patients. The overall pattern suggests a motivational disturbance in schizophrenia characterized by elements of both diminished approach and elevated withdrawal tendencies.
format	article
author	William P Horan Jonathan K Wynn Ian Mathis Gregory A Miller Michael F Green
author_facet	William P Horan Jonathan K Wynn Ian Mathis Gregory A Miller Michael F Green
author_sort	William P Horan
title	Approach and withdrawal motivation in schizophrenia: an examination of frontal brain asymmetric activity.
title_short	Approach and withdrawal motivation in schizophrenia: an examination of frontal brain asymmetric activity.
title_full	Approach and withdrawal motivation in schizophrenia: an examination of frontal brain asymmetric activity.
title_fullStr	Approach and withdrawal motivation in schizophrenia: an examination of frontal brain asymmetric activity.
title_full_unstemmed	Approach and withdrawal motivation in schizophrenia: an examination of frontal brain asymmetric activity.
title_sort	approach and withdrawal motivation in schizophrenia: an examination of frontal brain asymmetric activity.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/198e19989a954148bcc943885b287812
work_keys_str_mv	AT williamphoran approachandwithdrawalmotivationinschizophreniaanexaminationoffrontalbrainasymmetricactivity AT jonathankwynn approachandwithdrawalmotivationinschizophreniaanexaminationoffrontalbrainasymmetricactivity AT ianmathis approachandwithdrawalmotivationinschizophreniaanexaminationoffrontalbrainasymmetricactivity AT gregoryamiller approachandwithdrawalmotivationinschizophreniaanexaminationoffrontalbrainasymmetricactivity AT michaelfgreen approachandwithdrawalmotivationinschizophreniaanexaminationoffrontalbrainasymmetricactivity
_version_	1718414325823045632

Approach and withdrawal motivation in schizophrenia: an examination of frontal brain asymmetric activity.

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