CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers. In this report, we demonstrate that phosphorylation of HPV16 E2 by CK2 promotes formation of a complex with the cellular protein...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Apurva T. Prabhakar, Claire D. James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T. Fontan, Xu Wang, Sarah H. Glass, Andreas Wieland, Mary M. Donaldson, Molly L. Bristol, Renfeng Li, Anthony W. Oliver, Laurence H. Pearl, Brian O. Smith, Iain M. Morgan
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/198e33f511a84547b225bf38fd4332b1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:198e33f511a84547b225bf38fd4332b1
record_format	dspace
spelling	oai:doaj.org-article:198e33f511a84547b225bf38fd4332b12021-11-03T21:52:35ZCK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle2150-751110.1128/mBio.01163-21https://doaj.org/article/198e33f511a84547b225bf38fd4332b12021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01163-21https://doaj.org/toc/2150-7511 Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers. In this report, we demonstrate that phosphorylation of HPV16 E2 by CK2 promotes formation of a complex with the cellular protein TopBP1 in vitroin vivoApurva T. PrabhakarClaire D. JamesDipon DasRaymonde OtoaMatthew DayJohn BurgnerChristian T. FontanXu WangSarah H. GlassAndreas WielandMary M. DonaldsonMolly L. BristolRenfeng LiAnthony W. OliverLaurence H. PearlBrian O. SmithIain M. MorganAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Apurva T. Prabhakar Claire D. James Dipon Das Raymonde Otoa Matthew Day John Burgner Christian T. Fontan Xu Wang Sarah H. Glass Andreas Wieland Mary M. Donaldson Molly L. Bristol Renfeng Li Anthony W. Oliver Laurence H. Pearl Brian O. Smith Iain M. Morgan CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle
description	Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers. In this report, we demonstrate that phosphorylation of HPV16 E2 by CK2 promotes formation of a complex with the cellular protein TopBP1 in vitroin vivo
format	article
author	Apurva T. Prabhakar Claire D. James Dipon Das Raymonde Otoa Matthew Day John Burgner Christian T. Fontan Xu Wang Sarah H. Glass Andreas Wieland Mary M. Donaldson Molly L. Bristol Renfeng Li Anthony W. Oliver Laurence H. Pearl Brian O. Smith Iain M. Morgan
author_facet	Apurva T. Prabhakar Claire D. James Dipon Das Raymonde Otoa Matthew Day John Burgner Christian T. Fontan Xu Wang Sarah H. Glass Andreas Wieland Mary M. Donaldson Molly L. Bristol Renfeng Li Anthony W. Oliver Laurence H. Pearl Brian O. Smith Iain M. Morgan
author_sort	Apurva T. Prabhakar
title	CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle
title_short	CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle
title_full	CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle
title_fullStr	CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle
title_full_unstemmed	CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle
title_sort	ck2 phosphorylation of human papillomavirus 16 e2 on serine 23 promotes interaction with topbp1 and is critical for e2 interaction with mitotic chromatin and the viral life cycle
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/198e33f511a84547b225bf38fd4332b1
work_keys_str_mv	AT apurvatprabhakar ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT clairedjames ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT dipondas ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT raymondeotoa ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT matthewday ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT johnburgner ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT christiantfontan ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT xuwang ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT sarahhglass ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT andreaswieland ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT marymdonaldson ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT mollylbristol ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT renfengli ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT anthonywoliver ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT laurencehpearl ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT brianosmith ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle AT iainmmorgan ck2phosphorylationofhumanpapillomavirus16e2onserine23promotesinteractionwithtopbp1andiscriticalfore2interactionwithmitoticchromatinandthevirallifecycle
_version_	1718445381028675584

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

Ejemplares similares